Obeng-Gyasi Emmanuel
Department of Built Environment, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA.
Med Sci (Basel). 2020 Aug 5;8(3):30. doi: 10.3390/medsci8030030.
Chronic physiological stress and hepatic injury were explored in this cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2010. Lead exposure was measured using Blood Lead Levels (BLL), which were divided into quartiles of exposure based on the distribution within the database. Allostatic load (AL), a variable representing chronic physiological stress, was operationalized using ten clinical markers. The geometric mean values for markers of liver injury of interest (a) Aspartate Aminotransferase (AST), (b) Alanine Aminotransferase (ALT), (c) Alkaline Phosphatase (ALP), and (d) Gamma glutamyl-transferase (GGT) were explored in quartiles of lead exposure. Associations between AL and AST, ALT, ALP, and GGT among those exposed to lead were analyzed using linear regression models. In examining lead exposure in increasing quartiles, the geometric mean of the liver injury markers showed significant elevations as lead exposure levels increased. Simple linear regression revealed AL was positively associated with several markers of hepatic injury in all degrees of lead exposure. This study demonstrates the potential dangers of social and environmental exposures to liver health.
在这项横断面研究中，利用2007 - 2010年美国国家健康与营养检查调查（NHANES）的数据，对慢性生理应激和肝损伤进行了探究。铅暴露通过血铅水平（BLL）来衡量，根据数据库中的分布情况将其分为四分位数暴露水平。使用十个临床指标来计算代表慢性生理应激的变量——应变负荷（AL）。在铅暴露的四分位数中，对感兴趣的肝损伤标志物（a）天冬氨酸转氨酶（AST）、（b）丙氨酸转氨酶（ALT）、（c）碱性磷酸酶（ALP）和（d）γ-谷氨酰转移酶（GGT）的几何平均值进行了探究。使用线性回归模型分析了铅暴露人群中AL与AST、ALT、ALP和GGT之间的关联。在检查铅暴露四分位数增加的情况时，随着铅暴露水平的升高，肝损伤标志物的几何平均值显示出显著升高。简单线性回归显示，在所有铅暴露程度下，AL与几种肝损伤标志物呈正相关。这项研究表明了社会和环境暴露对肝脏健康的潜在危害。
