非酒精性脂肪性肝病的发病机制及主要动物模型
Pathogenesis of and major animal models used for nonalcoholic fatty liver disease.
作者信息
Jiang Mingzuo, Wu Nan, Chen Xi, Wang Weijie, Chu Yi, Liu Hao, Li Wenjiao, Chen Di, Li Xiaowei, Xu Bing
机构信息
1 State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xijing Hospital, The Air-Force Military Medical University, Xi'an, Shaanxi, China.
2 Laboratory of Tissue Engineering, Faculty of Life Science, Northwest University, Xi'an, Shaanxi, China.
出版信息
J Int Med Res. 2019 Apr;47(4):1453-1466. doi: 10.1177/0300060519833527. Epub 2019 Mar 15.
Nonalcoholic fatty liver disease (NAFLD) and its pathologically more severe form, nonalcoholic steatohepatitis (NASH), have become prevalent worldwide and carry an increased risk of developing hepatocellular carcinoma and other metabolic diseases. Diverse animal models have been proposed to replicate particular characteristics of NAFLD and NASH and have provided significant clues to the critical molecular targets of NASH treatment. In this review, we summarize the histopathology, pathogenesis, and molecular basis of NAFLD progression and discuss the benchmark animal models of NAFLD/NASH.
非酒精性脂肪性肝病（NAFLD）及其病理上更为严重的形式，即非酒精性脂肪性肝炎（NASH），已在全球范围内普遍存在，并增加了患肝细胞癌和其他代谢性疾病的风险。人们提出了多种动物模型来复制NAFLD和NASH的特定特征，并为NASH治疗的关键分子靶点提供了重要线索。在本综述中，我们总结了NAFLD进展的组织病理学、发病机制和分子基础，并讨论了NAFLD/NASH的基准动物模型。
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