Zhang Ru, Guan Qing, Zhang Mengting, Ding Yajie, Tang Zongzhe, Wang Hongliang, Zhang Wei, Chen Yue, Jiang Rong, Cui Yan, Wang Jie
School of Nursing, Nanjing Medical University, Nanjing, People's Republic of China.
Department of General Practice, Community Health Service Center, Nanjing, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Oct 19;15:3167-3179. doi: 10.2147/DMSO.S383907. eCollection 2022.
Insulin resistance (IR) is a major factor involved in the pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD). Triglyceride-glucose (TyG) index, an easily detected surrogate marker of IR, has not been explored sufficiently on its relationship with incident MAFLD risk. This study sought to investigate the association of baseline TyG index with the risk of MAFLD in a Chinese cohort.
This health check-up cohort was constructed with eligible 2056 Chinese from a community. The TyG index was calculated as ln (fasting triglyceride [mg/dL]×fasting glucose [mg/dL]/2). Cox proportion hazard models were used to evaluate the longitudinal association between baseline TyG index and the risk of MAFLD.
During an average follow-up of 2.5 ± 0.5 years, about 12.8% of the subjects developed MAFLD, and the incidence of MAFLD trended to increase with the quartile TyG index ( < 0.05). After adjusting for all confounders, TyG index was independently correlated with the risk of incident MAFLD (HR = 1.784, 95% CI = 1.383-2.302, < 0.001), and the risk of MAFLD in the highest quartile of TyG index was two times higher than that in the lowest quartile (95% CI = 1.377-2.992, = 0.001). The restricted cubic spline analysis showed that the relationship between TyG index and the risk of MAFLD was linear in males ( for total < 0.001; for non-linearity = 0.746), but nonlinear in females ( for non-linearity = 0.040).
A high baseline TyG index was independently associated with a high risk of incident MAFLD, and we might develop the strategy of MAFLD prevention based on the TyG index.
胰岛素抵抗（IR）是代谢功能障碍相关脂肪性肝病（MAFLD）发病机制中的一个主要因素。甘油三酯-葡萄糖（TyG）指数作为一种易于检测的IR替代标志物，其与MAFLD发病风险的关系尚未得到充分研究。本研究旨在探讨中国队列中基线TyG指数与MAFLD风险的关联。
该健康体检队列由来自一个社区的2056名符合条件的中国人组成。TyG指数的计算方法为ln（空腹甘油三酯[mg/dL]×空腹血糖[mg/dL]/2）。采用Cox比例风险模型评估基线TyG指数与MAFLD风险之间的纵向关联。
在平均2.5±0.5年的随访期间，约12.8%的受试者发生了MAFLD，且MAFLD的发病率随TyG指数四分位数的增加而呈上升趋势（P<0.05）。在调整所有混杂因素后，TyG指数与MAFLD发病风险独立相关（HR = 1.784，95%CI = 1.383-2.302，P<0.001），TyG指数最高四分位数组的MAFLD风险是最低四分位数组的两倍（95%CI = 1.377-2.992，P = 0.001）。受限立方样条分析显示，TyG指数与MAFLD风险之间的关系在男性中呈线性（总体P<0.001；非线性P = 0.746），而在女性中呈非线性（非线性P = 0.040）。
高基线TyG指数与MAFLD发病高风险独立相关，我们可能会基于TyG指数制定MAFLD的预防策略。
