先露因素和新生儿结局在接受经皮激光凝固术后发生短暂供者水肿的双胎输血综合征病例中的作用：一项病例对照研究。
Predisposing factors and neonatal outcomes for twin-twin transfusion syndrome cases developing transient donor hydrops after fetoscopic laser coagulation: a case control study.
机构信息
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan, Taiwan.
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, 5, Fu-Shin Street, Kweishan, Taoyuan, Taiwan, Republic of China, 333.
出版信息
BMC Pregnancy Childbirth. 2019 Mar 11;19(1):87. doi: 10.1186/s12884-019-2236-4.
BACKGROUND
Transient donor hydrops (TDH) is defined as donor hydrops developed within days after laser therapy for twin-twin transfusion syndrome (TTTS) followed by resolution later. The purpose of this study was to evaluate the incidence, neonatal outcomes and predisposing factors of post laser therapy TDH in severe TTTS.
METHODS
A total of 142 patients with severe TTTS who received laser therapy were included into this study. The pre-operative characteristics and neonatal outcomes were compared between TTTS with and without post laser therapy TDH. All live neonates received cranial ultrasound examination after delivery, mild cerebral injury was defined as exhibiting at least one of the following: intraventricular hemorrhage (IVH) grade I and II, lenticulostriate vasculopathy and subependymal pseudocysts; severe cerebral injury comprised at least one among the following: IVH grade III or grade IV, cystic periventriculoleukomalacia (PVL) grade II or more, porencephalic cysts, and ventricular dilatation. Fetal survival was defined as living more than 30 days after delivery.
背景
短暂性供体水肿（TDH）是指在接受激光治疗双胎输血综合征（TTTS）后数天内发生的供体水肿，并随后消退。本研究的目的是评估严重 TTTS 患者激光治疗后 TDH 的发生率、新生儿结局和易患因素。
方法
本研究共纳入 142 例接受激光治疗的严重 TTTS 患者。比较了有和无激光治疗后 TDH 的 TTTS 患者的术前特征和新生儿结局。所有存活新生儿在分娩后均接受头颅超声检查，轻度脑损伤定义为至少存在以下一种情况：脑室内出血（IVH）Ⅰ级和Ⅱ级、纹状体血管病和室管膜下假性囊肿；重度脑损伤包括以下至少一种情况：IVH Ⅲ级或Ⅳ级、囊性脑室周围白质软化（PVL）Ⅱ级或更高级别、脑裂畸形和脑室扩张。胎儿存活定义为分娩后存活超过 30 天。
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