Kaila Marianne, Marjoniemi Jasmine, Nokireki Tiina
Virology Unit, Finnish Food Authority, Mustialankatu 3, 00790, Helsinki, Finland.
University of Helsinki, P.O. Box 66, 00014, Helsinki, Finland.
Acta Vet Scand. 2019 Mar 14;61(1):15. doi: 10.1186/s13028-019-0450-8.
Seventy-two canine serum samples were analyzed for post-vaccination serum titers of rabies antibodies. The samples were divided into two groups: Group 1 dogs (n = 36) were imported dogs from the Russian Federation (n = 31) or Romania (n = 5), with a mean serum antibody titer value of 1.54 IU/mL. Group 2 dogs (n = 36) were Finnish dogs vaccinated in Finland, with a mean titer of 4.19 IU/mL. Altogether, 14 (39%) dogs (CI 95% 23-56) were without detectable antibodies (≤ 0.1 IU/mL) in Group 1, whereas in Group 2, all dogs had an antibody titer greater than 0.1 IU/mL. A statistically significant difference was observed between these groups when comparing the proportions of dogs with antibody levels less than or exceeding 0.5 IU/mL. In Group 1, 19 out of the 36 dogs (CI 95% 36-70) had serum titer values < 0.5 IU/mL, while in Group 2, only 2 dogs had serum titer values < 0.5 IU/mL. Despite the small sample size, this raises concern over the imported dogs having insufficient antibody levels required for international travel and implies that these dogs had perhaps not been vaccinated, even though they had documentation of vaccination upon arrival.
对72份犬血清样本进行了狂犬病抗体疫苗接种后血清滴度分析。样本分为两组：第1组犬（n = 36）为从俄罗斯联邦（n = 31）或罗马尼亚（n = 5）进口的犬，平均血清抗体滴度值为1.54 IU/mL。第2组犬（n = 36）为在芬兰接种疫苗的芬兰犬，平均滴度为4.19 IU/mL。第1组中共有14只（39%）犬（95%置信区间23 - 56）未检测到抗体（≤0.1 IU/mL），而在第2组中，所有犬的抗体滴度均大于0.1 IU/mL。比较抗体水平低于或超过0.5 IU/mL的犬的比例时，两组之间观察到统计学上的显著差异。在第1组的36只犬中，有19只（95%置信区间36 - 70）血清滴度值<0.5 IU/mL，而在第2组中，只有2只犬的血清滴度值<0.5 IU/mL。尽管样本量较小，但这引发了对进口犬国际旅行所需抗体水平不足的担忧，这意味着这些犬可能没有接种疫苗，尽管它们在抵达时有疫苗接种证明。
