膜联蛋白 A1 - 癌症的福音还是诅咒？

Annexin-A1 - A Blessing or a Curse in Cancer?

机构信息

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), 28 Medical Drive, Level 3, Singapore 117456; NUS Immunology Program, Life Sciences Institute, NUS, Singapore; NUS Graduate School for Integrative Sciences and Engineering, NUS, Singapore; These authors contributed equally.

出版信息

Trends Mol Med. 2019 Apr;25(4):315-327. doi: 10.1016/j.molmed.2019.02.004. Epub 2019 Mar 11.

DOI:10.1016/j.molmed.2019.02.004

PMID:30871809

Abstract

Annexin-A1 (ANXA1), a potent endogenous immunomodulatory protein has been implicated in multiple functions essential in cancer, including cell proliferation, apoptosis, chemosensitivity, metastasis, and invasion. ANXA1 expression is varied depending on tumor type, and there are contradictory reports on its role in the regulation of proliferation and tumor growth. Here, we summarize the differing reports on cell proliferation and metastasis and attempt to discuss the reasons behind these different effects. ANXA1 plays a role as a homeostatic protein that regulates essential transcription factors and miRNAs. A more coherent understanding of ANXA1 in cancer could present a more biologically meaningful and clinically relevant strategy.

摘要

膜联蛋白 A1（ANXA1）是一种有效的内源性免疫调节蛋白，参与多种与癌症相关的重要功能，包括细胞增殖、凋亡、化疗敏感性、转移和侵袭。ANXA1 的表达因肿瘤类型而异，其在调节增殖和肿瘤生长中的作用存在相互矛盾的报道。在这里，我们总结了关于细胞增殖和转移的不同报道，并试图讨论这些不同影响背后的原因。ANXA1 作为一种调节重要转录因子和 miRNA 的稳态蛋白发挥作用。更全面地了解癌症中的 ANXA1 可能会提出更具生物学意义和临床相关性的策略。