膜联蛋白 A1 调节 TGF-β 信号通路并促进基底样乳腺癌细胞的转移形成。
Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells.
机构信息
Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, 2300 RA, Leiden, The Netherlands.
出版信息
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6340-5. doi: 10.1073/pnas.0913360107. Epub 2010 Mar 22.
Abstract
Annexin A1 (AnxA1) is a candidate regulator of the epithelial- to mesenchymal (EMT)-like phenotypic switch, a pivotal event in breast cancer progression. We show here that AnxA1 expression is associated with a highly invasive basal-like breast cancer subtype both in a panel of human breast cancer cell lines as in breast cancer patients and that AnxA1 is functionally related to breast cancer progression. AnxA1 knockdown in invasive basal-like breast cancer cells reduced the number of spontaneous lung metastasis, whereas additional expression of AnxA1 enhanced metastatic spread. AnxA1 promotes metastasis formation by enhancing TGFbeta/Smad signaling and actin reorganization, which facilitates an EMT-like switch, thereby allowing efficient cell migration and invasion of metastatic breast cancer cells.
摘要
膜联蛋白 A1（AnxA1）是上皮-间质（EMT）样表型转换的候选调节因子，这是乳腺癌进展中的一个关键事件。我们在这里表明，在一组人类乳腺癌细胞系和乳腺癌患者中，AnxA1 的表达与高度侵袭性的基底样乳腺癌亚型相关，并且 AnxA1 与乳腺癌的进展具有功能相关性。在侵袭性基底样乳腺癌细胞中敲低 AnxA1 可减少自发性肺转移的数量，而额外表达 AnxA1 则增强了转移的扩散。AnxA1 通过增强 TGFβ/Smad 信号和肌动蛋白重组来促进转移形成，从而促进 EMT 样转换，从而使转移性乳腺癌细胞能够有效地迁移和侵袭。
相似文献
1
Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells.膜联蛋白 A1 调节 TGF-β 信号通路并促进基底样乳腺癌细胞的转移形成。
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6340-5. doi: 10.1073/pnas.0913360107. Epub 2010 Mar 22.
2
Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis.膜联蛋白-1 与 NEMO 和 RIP1 相互作用，持续激活 IKK 复合物和 NF-κB：在乳腺癌转移中的作用。
Oncogene. 2011 Jul 14;30(28):3174-85. doi: 10.1038/onc.2011.28. Epub 2011 Mar 7.
3
Annexin A1 Preferentially Predicts Poor Prognosis of Basal-Like Breast Cancer Patients by Activating mTOR-S6 Signaling.膜联蛋白A1通过激活mTOR-S6信号通路，优先预测基底样乳腺癌患者的不良预后。
PLoS One. 2015 May 22;10(5):e0127678. doi: 10.1371/journal.pone.0127678. eCollection 2015.
4
The role of annexin A1 in expression of matrix metalloproteinase-9 and invasion of breast cancer cells.膜联蛋白 A1 在基质金属蛋白酶-9 表达和乳腺癌细胞侵袭中的作用。
Biochem Biophys Res Commun. 2012 Jun 22;423(1):188-94. doi: 10.1016/j.bbrc.2012.05.114. Epub 2012 May 26.
5
Annexin A1 attenuates EMT and metastatic potential in breast cancer.膜联蛋白 A1 可减轻乳腺癌中的 EMT 和转移潜能。
EMBO Mol Med. 2010 Oct;2(10):401-14. doi: 10.1002/emmm.201000095.
6
Annexin A1 Expression Is Associated with Epithelial-Mesenchymal Transition (EMT), Cell Proliferation, Prognosis, and Drug Response in Pancreatic Cancer.膜联蛋白 A1 的表达与胰腺癌中的上皮-间充质转化（EMT）、细胞增殖、预后和药物反应有关。
Cells. 2021 Mar 15;10(3):653. doi: 10.3390/cells10030653.
7
ANXA4 Activates JAK-STAT3 Signaling by Interacting with ANXA1 in Basal-Like Breast Cancer.膜联蛋白 A4 通过与基底样乳腺癌中的膜联蛋白 A1 相互作用激活 JAK-STAT3 信号通路。
DNA Cell Biol. 2020 Sep;39(9):1649-1656. doi: 10.1089/dna.2020.5570. Epub 2020 Jun 16.
8
Annexin A1-suppressed autophagy promotes nasopharyngeal carcinoma cell invasion and metastasis by PI3K/AKT signaling activation.膜联蛋白 A1 抑制自噬通过 PI3K/AKT 信号通路激活促进鼻咽癌细胞侵袭和转移。
Cell Death Dis. 2018 Nov 20;9(12):1154. doi: 10.1038/s41419-018-1204-7.
9
ANXA1 inhibits miRNA-196a in a negative feedback loop through NF-kB and c-Myc to reduce breast cancer proliferation.膜联蛋白A1通过核因子-κB和c-Myc在负反馈回路中抑制微小RNA-196a，以减少乳腺癌增殖。
Oncotarget. 2016 May 10;7(19):27007-20. doi: 10.18632/oncotarget.8875.
10
Inhibition of Androgen Receptor Signaling Promotes Prostate Cancer Cell Migration via Upregulation of Annexin A1 Expression.抑制雄激素受体信号通路通过上调膜联蛋白 A1 的表达促进前列腺癌细胞迁移。
Arch Med Res. 2021 Feb;52(2):174-181. doi: 10.1016/j.arcmed.2020.10.005. Epub 2020 Oct 13.
引用本文的文献
1
Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial.肿瘤性pSMAD2作为早期乳腺癌的预后生物标志物：来自随机SweBCG91RT试验的见解
Breast Cancer Res Treat. 2025 Jun 9. doi: 10.1007/s10549-025-07744-0.
2
Roles of Annexin A1 Expression in Small Cell Lung Cancer.膜联蛋白A1表达在小细胞肺癌中的作用。
Cancers (Basel). 2025 Apr 23;17(9):1407. doi: 10.3390/cancers17091407.
3
A Broad-Spectrum Chemokine Inhibitor Drives M2 Macrophage Polarization Through Modulation of the Myometrial Secretome.一种广谱趋化因子抑制剂通过调节子宫肌层分泌组驱动M2巨噬细胞极化。
Cells. 2025 Mar 30;14(7):514. doi: 10.3390/cells14070514.
4
Eosinophils-Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF-β Pathway Mediated by Anxa1 Binding.嗜酸性粒细胞诱导滑膜成纤维细胞分泌核心蛋白聚糖通过膜联蛋白A1结合介导的转化生长因子-β途径减轻软骨降解。
Adv Sci (Weinh). 2025 Aug;12(29):e2416030. doi: 10.1002/advs.202416030. Epub 2025 Mar 24.
5
Peptide Aptamer-Paclitaxel Conjugates for Tumor Targeted Therapy.用于肿瘤靶向治疗的肽适配体-紫杉醇缀合物
Pharmaceutics. 2024 Dec 30;17(1):40. doi: 10.3390/pharmaceutics17010040.
6
Combination of polymeric micelle formulation of TGFβ receptor inhibitors and paclitaxel produces consistent response across different mouse models of Triple-negative breast cancer.转化生长因子β受体抑制剂的聚合物胶束制剂与紫杉醇联合使用，在不同的三阴性乳腺癌小鼠模型中均产生了一致的反应。
Bioeng Transl Med. 2024 Jun 4;9(5):e10681. doi: 10.1002/btm2.10681. eCollection 2024 Sep.
7
Mechano-gradients drive morphogen-noise correction to ensure robust patterning.机械梯度驱动形态发生素噪声校正以确保稳健的图案形成。
Sci Adv. 2024 Nov 15;10(46):eadp2357. doi: 10.1126/sciadv.adp2357.
8
Identification of ANXA1 as a Novel Upstream Negative Regulator of Notch1 Function in AML.鉴定膜联蛋白A1作为急性髓系白血病中Notch1功能的新型上游负调控因子
Adv Sci (Weinh). 2024 Dec;11(48):e2409726. doi: 10.1002/advs.202409726. Epub 2024 Oct 24.
9
Identification of genes contributing to attenuation of rat model of galactose-induced cataract by pyruvate.鉴定丙酮酸减轻半乳糖诱导大鼠白内障模型的相关基因。
Genes Cells. 2024 Oct;29(10):876-888. doi: 10.1111/gtc.13150. Epub 2024 Sep 1.
10
The Immune Response of Cancer Cells in Breast and Gynecologic Neoplasms.乳腺癌和妇科肿瘤中的癌细胞免疫反应。
Int J Mol Sci. 2024 Jun 5;25(11):6206. doi: 10.3390/ijms25116206.
本文引用的文献
1
Regulatory aspects of genetic research with residual human tissue: effective and efficient data coding.人类残余组织基因研究的监管方面：有效且高效的数据编码
Eur J Cancer. 2009 Sep;45(13):2376-82. doi: 10.1016/j.ejca.2009.03.008. Epub 2009 Apr 10.
2
Annexin A2-dependent polymerization of actin mediates endosome biogenesis.膜联蛋白A2依赖性肌动蛋白聚合介导内体生物发生。
Dev Cell. 2009 Mar;16(3):445-57. doi: 10.1016/j.devcel.2009.01.007.
3
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits.上皮细胞与间充质细胞状态之间的转变：恶性特征和干细胞特征的获得。
Nat Rev Cancer. 2009 Apr;9(4):265-73. doi: 10.1038/nrc2620. Epub 2009 Mar 5.
4
Endocytic regulation of TGF-beta signaling.转化生长因子-β信号通路的内吞调节
Cell Res. 2009 Jan;19(1):58-70. doi: 10.1038/cr.2008.315.
5
Annexin A2 binding to endosomes and functions in endosomal transport are regulated by tyrosine 23 phosphorylation.膜联蛋白A2与内体的结合及在内体运输中的功能受酪氨酸23磷酸化的调控。
J Biol Chem. 2009 Jan 16;284(3):1604-11. doi: 10.1074/jbc.M806499200. Epub 2008 Nov 5.
6
Annexin A8 regulates late endosome organization and function.膜联蛋白A8调节晚期内体的组织和功能。
Mol Biol Cell. 2008 Dec;19(12):5267-78. doi: 10.1091/mbc.e08-04-0383. Epub 2008 Oct 15.
7
Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer?转化生长因子-β信号传导：转移性乳腺癌中新兴的干细胞靶点？
Breast Cancer Res Treat. 2009 Jun;115(3):453-95. doi: 10.1007/s10549-008-0184-1. Epub 2008 Oct 9.
8
Epithelial mesenchymal transition traits in human breast cancer cell lines.人乳腺癌细胞系中的上皮-间质转化特征
Clin Exp Metastasis. 2008;25(6):629-42. doi: 10.1007/s10585-008-9170-6. Epub 2008 May 7.
9
TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4.转化生长因子β通过血管生成素样蛋白4使乳腺肿瘤易于发生肺转移播散。
Cell. 2008 Apr 4;133(1):66-77. doi: 10.1016/j.cell.2008.01.046.
10
Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype.乳腺癌中的上皮-间质转化与基底样表型相关。
Cancer Res. 2008 Feb 15;68(4):989-97. doi: 10.1158/0008-5472.CAN-07-2017.
Zotero 插件