Gizak Agnieszka, Duda Przemyslaw, Wisniewski Janusz, Rakus Dariusz
Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw, Poland.
Department of Molecular Physiology and Neurobiology, Wroclaw University, Wroclaw, Poland.
Adv Biol Regul. 2019 May;72:41-50. doi: 10.1016/j.jbior.2019.03.001. Epub 2019 Mar 9.
Fructose-1,6-bisphosphatase (FBPase) is one of the ancient, evolutionarily conserved enzymes of carbohydrate metabolism. It has been described for a first time in 1943, however, for the next half a century mostly kinetic and structural parameters of animal FBPases have been studied. Discovery of ubiquitous expression of the muscle isozyme of FBPase, thus far considered to merely regulate glycogen synthesis from carbohydrate precursors, and its nuclear localisation in several cell types has risen new interest in the protein, resulting in numerous publications revealing complex functions/properties of FBPase. This review summarises the current knowledge of FBPase in animal cells providing evidence that the enzyme merits the name of moonlighting protein.
果糖-1,6-二磷酸酶（FBPase）是碳水化合物代谢中古老且进化保守的酶之一。它于1943年首次被描述，然而，在接下来的半个世纪里，主要研究的是动物FBPase的动力学和结构参数。肌肉同工型FBPase的普遍表达（迄今为止一直被认为仅调节由碳水化合物前体合成糖原）及其在几种细胞类型中的核定位，引发了对该蛋白的新兴趣，从而产生了大量揭示FBPase复杂功能/特性的出版物。这篇综述总结了目前关于动物细胞中FBPase的知识，提供了该酶无愧于兼职蛋白这一名称的证据。
