美国慢性荨麻疹的患病率估计：一项性别和年龄调整的人群分析。
Prevalence estimates for chronic urticaria in the United States: A sex- and age-adjusted population analysis.
机构信息
Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.
Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.
出版信息
J Am Acad Dermatol. 2019 Jul;81(1):152-156. doi: 10.1016/j.jaad.2019.02.064. Epub 2019 Mar 11.
BACKGROUND
Disease burden in chronic urticaria (CU) is poorly understood.
OBJECTIVE
To estimate standardized overall and sex-, age-, and race-specific prevalence estimates for CU among adults in the United States.
METHODS
A cross-sectional analysis with electronic health records data for a demographically heterogeneous population-based sample of >55 million patients across all 4 census regions.
RESULTS
The overall CU prevalence was 0.23%, or 230 CU cases/100,000 adults. The adjusted prevalence in women was 310 (95% confidence interval [CI] 307-312) cases/100,000 adults, more than twice that of men (146 [95% CI 143-148] cases/100,000 adults, P < .001). CU prevalence was highest among patients aged 40-49 years (256 [95% CI 252-261] cases/100,000 adults) and 50-59 years (246 [95% CI 242-251] cases/100,000 adults) compared with all other age groups (P < .0001). Adjusted prevalences for black (292 [95% CI 285-298] cases/100,000 adults) and other (331 [95% CI 323-338] cases/100,000 adults) patients were higher than that for white patients (262 [95% CI 260-264] cases/100,000 adults; P < .001).
LIMITATIONS
Use of administrative data has the potential to underestimate burden.
CONCLUSION
There are >500,000 people estimated to have CU in the United States, most of whom are women or adults ≥40 years of age.
背景
慢性荨麻疹（CU）的疾病负担了解甚少。
目的
估计美国成年人 CU 的标准化总体患病率以及性别、年龄和种族特异性患病率。
方法
使用电子健康记录数据对来自四个普查区域的超过 5500 万患者进行基于人群的异质人群进行横断面分析。
结果
CU 的总体患病率为 0.23%，即每 10 万名成年人中有 230 例 CU 病例。女性调整后的患病率为 310（95%置信区间[CI]307-312）例/10 万成年人，是男性的两倍多（146 [95%CI 143-148] 例/10 万成年人，P <.001）。CU 患病率在 40-49 岁（256 [95%CI 252-261] 例/10 万成年人）和 50-59 岁（246 [95%CI 242-251] 例/10 万成年人）的患者中最高，与所有其他年龄组相比（P <.0001）。与白人患者（262 [95%CI 260-264] 例/10 万成年人；P <.001）相比，黑人（292 [95%CI 285-298] 例/10 万成年人）和其他种族（331 [95%CI 323-338] 例/10 万成年人）患者的调整后患病率更高。
局限性
使用行政数据可能会低估负担。
结论
美国估计有超过 50 万人患有 CU，其中大多数为女性或≥40 岁的成年人。
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