Faculty of Medicine, Federal University of Uberlândia, Uberlândia, MG, Brazil.
Department of Physiology, Federal University of São Paulo, São Paulo, SP, Brazil.
Sci Rep. 2019 Mar 14;9(1):4455. doi: 10.1038/s41598-019-40989-6.
The effects of circadian misalignment and work shift on oxidative stress profile of shift workers have not been explored in the literature. The present study aimed to evaluate the role of shift work (day and night) and social jetlag - a measure of circadian misalignment - with oxidative stress markers. A cross-sectional study was performed with 79 men (21-65 years old, 27.56 ± 4.0 kg/m) who worked the night shift (n = 37) or daytime (n = 42). The analyzed variables included anthropometric measures and determination of systemic levels of markers of oxidative damage and antioxidant defense. Social jetlag was calculated by the absolute difference between the mean sleep point on working and rest days. The night group presented higher systemic values of thiobarbituric acid reactive substances and hydrogen peroxide, and lower levels of nitrite, total antioxidant capacity, and catalase and superoxide dismutase activities in relation to the day group. However, social jetlag was not associated with oxidative stress-related biomarkers analyzed in the night group. These results suggest that the night worker has higher levels of oxidative stress damage and lower levels of antioxidant defenses, while social jetlag was not a possible responsible factor for this condition.
昼夜节律紊乱和轮班工作对轮班工人氧化应激谱的影响在文献中尚未得到探讨。本研究旨在评估轮班工作（白班和夜班）和社会时差（昼夜节律紊乱的一种衡量标准）与氧化应激标志物的关系。本研究采用横断面研究方法，共纳入 79 名男性（21-65 岁，27.56±4.0kg/m），其中夜班工作者（n=37）和白班工作者（n=42）。分析的变量包括人体测量指标以及系统氧化损伤和抗氧化防御标志物水平的测定。社会时差通过工作日和休息日平均睡眠时间的绝对差值来计算。与白班组相比，夜班组的丙二醛和过氧化氢的系统水平更高，而亚硝酸盐、总抗氧化能力、过氧化氢酶和超氧化物歧化酶活性更低。然而，社会时差与夜班组的氧化应激相关生物标志物无相关性。这些结果表明，夜班工人的氧化应激损伤水平更高，抗氧化防御水平更低，而社会时差并不是造成这种情况的可能因素。
