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大学和学术医院生物医学研究产生的知识产权的重要性。

Importance of intellectual property generated by biomedical research at universities and academic hospitals.

作者信息

Heus Joris J, de Pauw Elmar S, Mirjam Leloux, Margherita Morpurgo, Michael R Hamblin, Michal Heger

机构信息

Innovation Exchange Amsterdam (IXA) Office AMC, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.

Innovation Exchange Amsterdam (IXA) Office UvA-HvA, University of Amsterdam, Science Park 904, Amsterdam, the Netherlands.

出版信息

J Clin Transl Res. 2017 May 24;3(2):250-259. doi: 10.18053/jctres.03.201702.005.

Abstract

Biomedical research has many different facets. Researchers and clinicians study disease biology and biochemistry to discover novel therapeutic targets, unravel biochemical pathways and identify biomarkers to improve diagnosis, or devise new approaches to clinically manage diseases more effectively. In all instances, the overall goal of biomedical research is to ensure that results thereof (such as a therapy, a device, or a method which may be broadly referred to as "inventions") are clinically implemented. Most of the researchers' efforts are centered on the advance of technical and scientific aspects of an invention. The development and implementation of an invention can be arduous and very costly. Historically, it has proven to be crucial to protect intellectual property rights (IPR) to an invention (i.e., a patent) to ensure that companies can obtain a fair return on their investment that is needed to develop an academic invention into a product for the benefit of patients. However, the importance of IPR is not generally acknowledged among researchers at academic institutions active in biomedical research. Therefore this paper aims to (1) raise IP awareness amongst clinical and translational researchers; (2) provide a concise overview of what the patenting trajectory entails; and (3) highlight the importance of patenting for research and the researcher. : Adequate patent protection of inventions generated through biomedical research at academic institutions increases the probability that patients will benefit from these inventions, and indirectly enables the financing of clinical studies, mainly by opening up funding opportunities (e.g. specific grants aimed at start-ups, pre-seed and seed capital) that otherwise would not be accessible. As a consequence, patented inventions are more likely to become clinically tested and reach the market, providing patients with more treatment options.

摘要

生物医学研究有许多不同的方面。研究人员和临床医生研究疾病生物学和生物化学,以发现新的治疗靶点、揭示生化途径、识别生物标志物以改善诊断,或设计新方法更有效地临床管理疾病。在所有情况下,生物医学研究的总体目标是确保其成果(如一种疗法、一种设备或一种方法,可统称为“发明”)得以临床应用。大多数研究人员的努力都集中在发明的技术和科学层面的推进上。一项发明的开发和应用可能艰巨且成本高昂。从历史上看,事实证明保护发明的知识产权(即专利)至关重要,以确保公司能够从将学术发明开发成造福患者的产品所需的投资中获得合理回报。然而,在积极开展生物医学研究的学术机构中,研究人员普遍未认识到知识产权的重要性。因此,本文旨在:(1)提高临床和转化研究人员的知识产权意识;(2)简要概述专利申请流程;(3)强调专利申请对研究及研究人员的重要性。学术机构通过生物医学研究产生的发明获得充分的专利保护,会增加患者从这些发明中受益的可能性,并且主要通过开辟原本无法获得的资金机会(如针对初创企业、种子前和种子资本的特定资助),间接为临床研究提供资金。因此,获得专利的发明更有可能进行临床试验并推向市场,为患者提供更多治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b32/6410672/ac6a1c638e64/jclintranslres-3-250-g001.jpg

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