Meng Xiao, Chen Changqing, Deng Xinyuan, Wang Zhangyuan, Chen Qi, Ma Yuguo
Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Soft Matter Science and Engineering, Key Lab of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry, Peking University, Beijing, 100871, P. R. China.
Department of Chemistry and Physics, Salem State University, 352 Lafayette Street, Salem, MA, 01970, USA.
Chemistry. 2019 May 23;25(29):7142-7148. doi: 10.1002/chem.201900391. Epub 2019 Apr 11.
Facilitated by the supramolecular synthons of carboxylic acids and amides through cooperative hydrogen-bonding and arene-perfluoroarene interactions, the azide-alkyne cycloaddition reaction between two different molecules in a cocrystal was achieved. This reaction could be accelerated by pressure using a common hydraulic press equipment with excellent regioselectivity to yield 1,4-triazole products. The absence of decarboxylation side reactions in the products in the solid state demonstrated that this strategy can provide a green synthetic route for products not directly accessible by traditional syntheses in solution.
