Is multiplexed off-axis holography for quantitative phase imaging more spatial bandwidth-efficient than on-axis holography? [Invited].

Digital holographic microcopy is a thriving imaging modality that attracts considerable research interest due to its ability not only to create excellent label-free contrast but also to supply valuable physical information regarding the density and dimensions of the sample with nanometer-scale axial sensitivity. Three basic holographic recording geometries currently exist, including on-axis, off-axis, and slightly off-axis holography, each of which enables a variety of architectures in terms of bandwidth use and compression capacity. Specifically, off-axis holography and slightly off-axis holography allow spatial hologram multiplexing, enabling one to compress more information into the same digital hologram. In this paper, we define an efficiency score to analyze the various possible architectures and compare the signal-to-noise ratio and the mean squared error obtained using each of them, thus determining the optimal holographic method.