Lun Michael C, Li Changqing
Appl Opt. 2019 Feb 1;58(4):1084-1092. doi: 10.1364/AO.58.001084.
X-ray luminescence computed tomography (XLCT) is an emerging hybrid imaging modality. It has been recently reported that materials such as water, tissue, or even air can generate optical photons upon x-ray irradiation, which can increase the noises in measurements of XLCT. In this study, we have investigated the x-ray luminescence from water, air, as well as tissue mimicking phantoms, including one embedded with a 0.01 mg/mL GOS:Eu microphosphor target. We have measured the optical emission spectrum from each sample, including samples of meat and fat, using a spectrograph. Our results indicate that there are plenty of optical photons emitted by x-ray irradiation, and a small nanophosphor concentration, as low as 5.28 μM in a deep background, can provide enough contrast for XLCT imaging.
X射线发光计算机断层扫描（XLCT）是一种新兴的混合成像模式。最近有报道称，水、组织甚至空气等物质在X射线照射下会产生光学光子，这会增加XLCT测量中的噪声。在本研究中，我们研究了水、空气以及仿组织体模的X射线发光，其中包括一个嵌入了0.01 mg/mL GOS:Eu微磷光体靶标的体模。我们使用光谱仪测量了每个样品的光发射光谱，包括肉类和脂肪样品。我们的结果表明，X射线照射会发射大量光学光子，并且低至5.28 μM的低纳米磷光体浓度在深背景下也可为XLCT成像提供足够的对比度。
