Liu Xin, Liao Qimei, Wang Hongkai
IEEE Trans Biomed Eng. 2014 Jun;61(6):1621-7. doi: 10.1109/TBME.2013.2294633.
X-ray luminescence computed tomography (XLCT) opens new possibilities to perform molecular imaging with X-ray. However, challenges remain in dynamic XLCT imaging, where short scan time, good spatial resolution, and whole-body field of view should be considered simultaneously. In this paper, by the use of a single-view XLCT reconstruction method based on a compressive sensing (CS) technique, incorporating a cone beam XLCT imaging system, we implement fast 3-D XLCT imaging. To evaluate the performance of the method, two types of phantom experiments were performed based on a cone beam XLCT imaging system. In Case 1, one tube filled with the X-ray-excitable nanophosphor (Gd 2O 3 :Eu (3+)) was immerged in different positions in the phantom to evaluate the effect of the source position on single-view XLCT reconstruction accuracy. In Case 2, two tubes filled with Gd 2O 3 :Eu (3+) were immerged in different heights in the phantom to evaluate the whole-body imaging performance of single-view XLCT reconstruction. The experimental results indicated that the tubes used in previous phantom experiments can be resolved from single-view XCLT reconstruction images. The location error is less than 1.2 mm. In addition, since only one view data are needed to implement 3-D XLCT imaging, the acquisition time can be greatly reduced (∼1 frame/s) compared with previous XLCT systems. Hence, the technique is suited for imaging the fast distribution of the X-ray-excitable nanophosphors within a biological object.
X射线发光计算机断层扫描（XLCT）为利用X射线进行分子成像开辟了新的可能性。然而，动态XLCT成像仍面临挑战，在这种成像中，需要同时考虑短扫描时间、良好的空间分辨率和全身视野。在本文中，通过使用基于压缩感知（CS）技术的单视图XLCT重建方法，并结合锥束XLCT成像系统，我们实现了快速三维XLCT成像。为了评估该方法的性能，基于锥束XLCT成像系统进行了两种类型的体模实验。在案例1中，将一根装有X射线可激发纳米磷光体（Gd2O3:Eu(3+)）的管子浸入体模中的不同位置，以评估源位置对单视图XLCT重建精度的影响。在案例2中，将两根装有Gd2O3:Eu(3+)的管子浸入体模中的不同高度，以评估单视图XLCT重建的全身成像性能。实验结果表明，先前体模实验中使用的管子可以从单视图XCLT重建图像中分辨出来。定位误差小于1.2毫米。此外，由于实现三维XLCT成像只需要一个视图的数据，与先前的XLCT系统相比，采集时间可以大大减少（约1帧/秒）。因此，该技术适用于对生物体内X射线可激发纳米磷光体的快速分布进行成像。
