[先天性免疫在骨关节炎发病机制中的作用与进展]
[Role and progress of innate immunity in pathogenesis of osteoarthritis].
作者信息
Xie Jinwei, Huang Zeyu, Pei Fuxing
机构信息
Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2019 Mar 15;33(3):370-376. doi: 10.7507/1002-1892.201810068.
OBJECTIVE
To review and summarize the role and progress of innate immunity in the pathogenesis of osteoarthritis (OA).
METHODS
The domestic and foreign literature in recent years was reviewed. The role of innate immune-mediated inflammation, macrophages, T cells, and complement systems in the pathogenesis of OA, potential therapeutic targets, and the latest research progress were summarized.
RESULTS
With the deepening of research, OA is gradually considered as a low-grade inflammation, in which innate immunity plays an important role. The polarization of synovial macrophage subpopulation in OA has been studied extensively. Current data shows that the failure of transformation from M1 subtype to M2 subtype is a key link in the progression of OA. T cells and complement system are also involved in the pathological process of OA.
CONCLUSION
At present, the role of innate immunity in the progress of OA has been played in the spotlight, whereas the specific mechanism has not been clear. The macrophage subtype polarization is a potential therapeutic target for early prevention and treatment of OA.
目的
回顾和总结固有免疫在骨关节炎（OA）发病机制中的作用及研究进展。
方法
查阅近年来国内外文献，总结固有免疫介导的炎症、巨噬细胞、T细胞和补体系统在OA发病机制中的作用、潜在治疗靶点及最新研究进展。
结果
随着研究的深入，OA逐渐被认为是一种低度炎症，固有免疫在其中发挥重要作用。OA中滑膜巨噬细胞亚群的极化已得到广泛研究。目前数据表明，从M1亚型向M2亚型转化失败是OA进展的关键环节。T细胞和补体系统也参与OA的病理过程。
结论
目前，固有免疫在OA进展中的作用备受关注，但其具体机制尚不清楚。巨噬细胞亚型极化是OA早期预防和治疗的潜在治疗靶点。
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