[辅助性T细胞在骨关节炎发病机制中的作用]
[The role of helper T cell in the pathogenesis of osteoarthritis].
作者信息
Yang Dinglong, Zhang Zhiqiang
机构信息
Shanxi Medical University, Taiyuan Shanxi, 030000, P.R.China.
Department of Joint Surgery, Second Hospital of Shanxi Medical University, Taiyuan Shanxi, 030000, P.R.China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2020 Jul 15;34(7):932-938. doi: 10.7507/1002-1892.201910063.
OBJECTIVE
To review and summarize the role of helper T cell (Th) in the pathogenesis of osteoarthritis (OA) and research progress of Th cell-related treatment for OA.
METHODS
The domestic and foreign literature in recent years was reviewed. The role of Th cells [Th1, Th2, Th9, Th17, Th22, and follicular helper T cell (Tfh)] and related cytokines in the pathogenesis of OA and the latest research progress of treatment were summarized.
RESULTS
Th cells play an important role in the pathogenesis of OA. Th1, Th9, and Th17 cells are more important than Th2, Th22, and Tfh cells in the pathogenesis of OA. Cytokines such as tumor necrosis factor α and interleukin 17 can cause damage to articular cartilage significantly.
CONCLUSION
At present, the role of Th cells in the pathogenesis of OA has been played in the spotlight. The specific mechanism has not been clear. Regulating the Th cell-associated cytokines, intracellular and extracellular signals, and cellular metabolism is a potential method for prevention and treatment of OA.
目的
综述并总结辅助性T细胞（Th）在骨关节炎（OA）发病机制中的作用以及Th细胞相关治疗OA的研究进展。
方法
回顾近年来国内外文献。总结Th细胞[Th1、Th2、Th9、Th17、Th22和滤泡辅助性T细胞（Tfh）]及其相关细胞因子在OA发病机制中的作用以及治疗的最新研究进展。
结果
Th细胞在OA发病机制中起重要作用。在OA发病机制中，Th1、Th9和Th17细胞比Th2、Th22和Tfh细胞更重要。肿瘤坏死因子α和白细胞介素17等细胞因子可显著损伤关节软骨。
结论
目前，Th细胞在OA发病机制中的作用备受关注。具体机制尚不清楚。调节Th细胞相关细胞因子、细胞内外信号及细胞代谢是预防和治疗OA的潜在方法。
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