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Analysis of miRNA, mRNA, and TF interactions through network-based methods.通过基于网络的方法分析微小RNA、信使核糖核酸和转录因子的相互作用。
EURASIP J Bioinform Syst Biol. 2015 Jun 4;2015:4. doi: 10.1186/s13637-015-0023-8. eCollection 2015 Dec.
2
Quantitative study on morphology of calcified cartilage zone in OARSI 0∼4 cartilage from osteoarthritic knees.骨关节炎膝关节 OARSI0∼4 软骨钙化软骨带形态的定量研究。
Curr Res Transl Med. 2016 Jul-Sep;64(3):149-154. doi: 10.1016/j.retram.2016.01.009. Epub 2016 Jun 1.
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Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment.基因调控元件周围非编码RNA转录在转录因子招募中的作用。
RNA Biol. 2017 Jan 2;14(1):1-5. doi: 10.1080/15476286.2016.1248020. Epub 2016 Oct 20.
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Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration.鉴定 microRNA-181a-5p 和 microRNA-4454 作为小关节软骨退变的介质。
JCI Insight. 2016 Aug 4;1(12):e86820. doi: 10.1172/jci.insight.86820.
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A method for concise reporting of joint reaction forces orientation during gait.一种在步态期间简洁报告关节反作用力方向的方法。
J Biomech. 2016 Oct 3;49(14):3538-3542. doi: 10.1016/j.jbiomech.2016.08.005. Epub 2016 Aug 8.
6
Inhibition of microRNA-449a prevents IL-1β-induced cartilage destruction via SIRT1.抑制微小RNA-449a可通过沉默信息调节因子1（SIRT1）预防白细胞介素-1β（IL-1β）诱导的软骨破坏。
Osteoarthritis Cartilage. 2016 Dec;24(12):2153-2161. doi: 10.1016/j.joca.2016.07.002. Epub 2016 Jul 12.
7
Image-Guided Hyaluronic Acid Injection and Knee Bracing Significantly Improve Clinical Outcomes for High-Grade Osteoarthritis.影像引导下透明质酸注射及膝关节支具显著改善重度骨关节炎的临床疗效。
Sports Med Open. 2015;1(1):31. doi: 10.1186/s40798-015-0029-5. Epub 2015 Sep 15.
8
Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation.与软骨细胞细胞外基质相关的环状RNA通过作为miR-136的“海绵”发挥作用来调节人软骨降解中的MMP13表达。
Sci Rep. 2016 Mar 2;6:22572. doi: 10.1038/srep22572.
9
MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes.微小RNA-33a调节骨关节炎软骨细胞中胆固醇合成及胆固醇流出相关基因。
Arthritis Res Ther. 2015 Mar 5;17(1):42. doi: 10.1186/s13075-015-0556-y.
10
Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients.膝关节骨关节炎患者软骨中长链非编码RNA的表达谱
Osteoarthritis Cartilage. 2015 Mar;23(3):423-32. doi: 10.1016/j.joca.2014.12.001. Epub 2014 Dec 15.

[非编码RNA调控骨关节炎的分子生物学研究进展]

[Molecular biological research progress of non-coding RNAs modulating osteoarthritis].

作者信息

Jia Di, Li Yanlin, Wang Kun, Cai Guofeng, Yang Lingjian, Meng Xuhan

机构信息

Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Yunnan, 650000, P.R.China.

Department of Sports Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Yunnan, 650000,

出版信息

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Mar 15;31(3):374-378. doi: 10.7507/1002-1892.201610123.

DOI:10.7507/1002-1892.201610123
PMID:29806271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8458122/
Abstract

OBJECTIVE

To summarize the molecular biological research progress of non-coding RNAs modulating osteoarthritis (OA), and provide a reference basis for biological study and clinical treatment of OA.

METHODS

Recent domestic and foreign related literature about the regulation of OA pathological process by non-coding RNAs was widely reviewed.

RESULTS

Non-coding RNAs can be divided into three types based on the length of RNA. A lot of non-coding RNAs participating in OA pathological process are screened out by high throughput sequencing technology and microarray technology, and it is verified that these non-coding RNAs involve in the regulation of OA by RT-PCR. The mechanism of OA mediated target is clarified by knocking-down and overexpressing of the most prominent expressed non-coding RNAs in OA. There are the complicated gene expressed network topology in non-coding RNAs, and between non-coding RNAs and coding RNAs. It provides a basis for clearing the effect of gene structure and function, and finding the definite therapeutic target of OA.

CONCLUSION

There is preliminary study on molecular biological mechanism of non-coding RNAs mediating OA, but the key structure or sequence of non-coding RNAs, formation and interaction of effecting composite structure about mediating OA are unknown, and it needs further study.

摘要

目的

总结非编码RNA调控骨关节炎（OA）的分子生物学研究进展，为OA的生物学研究及临床治疗提供参考依据。

方法

广泛查阅国内外近期关于非编码RNA调控OA病理过程的相关文献。

结果

非编码RNA根据RNA长度可分为三类。通过高通量测序技术和基因芯片技术筛选出许多参与OA病理过程的非编码RNA，并通过逆转录聚合酶链反应（RT-PCR）验证这些非编码RNA参与OA的调控。通过敲低和过表达OA中表达最突出的非编码RNA来阐明OA介导靶点的机制。非编码RNA之间以及非编码RNA与编码RNA之间存在复杂的基因表达网络拓扑结构。这为明确基因结构和功能的作用以及寻找OA确切的治疗靶点提供了依据。

结论

关于非编码RNA介导OA的分子生物学机制已有初步研究，但非编码RNA的关键结构或序列、介导OA的效应复合结构的形成及相互作用尚不清楚，有待进一步研究。