1 AIDS Program, Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut.
2 Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
LGBT Health. 2018 Nov/Dec;5(8):477-483. doi: 10.1089/lgbt.2017.0186.
Globally, transgender women (TGW) experience a high burden of adverse health outcomes, including a high prevalence of HIV and sexually transmitted infections (STIs) as well as psychiatric disorders and substance use disorders. To address gaps in HIV research in Peru focused specifically on TGW, this study presents characteristics of a sample of HIV-positive TGW and identifies factors associated with viral suppression.
Between June 2015 and August 2016, 50 HIV-positive TGW were recruited in Lima, Peru. Multivariable logistic regression was used to identify factors associated with viral suppression (<200 copies/mL) among the TGW.
Among TGW, 85% achieved viral suppression. Approximately half (54%) reported anal sex with more than five partners in the past 6 months, 38% reported sex work, 68% had not disclosed their HIV status to one or more of their partners, and 38% reported condomless sex with their last partner. The prevalence of alcohol use disorders was high (54%), and 38% reported use of drugs in the past year. Moderate-to-severe drug use significantly reduced odds of achieving viral suppression (adjusted odds ratio 0.69; 95% confidence interval: 0.48-0.98).
Our findings highlight the need for integrated treatment for substance disorders in HIV care to increase the viral suppression rate among TGW in Lima, Peru.
在全球范围内,跨性别女性(TGW)面临着沉重的健康问题负担,包括 HIV 和性传播感染(STI)的高发率,以及精神障碍和物质使用障碍。为了解决秘鲁在 HIV 研究方面针对 TGW 的空白,本研究介绍了一组 HIV 阳性 TGW 的特征,并确定了与病毒抑制相关的因素。
在 2015 年 6 月至 2016 年 8 月期间,在秘鲁利马招募了 50 名 HIV 阳性 TGW。采用多变量逻辑回归分析确定了与 TGW 病毒抑制(<200 拷贝/ml)相关的因素。
在 TGW 中,85%的人实现了病毒抑制。约一半(54%)报告在过去 6 个月内与超过 5 名性伴侣发生过肛交,38%报告从事性工作,68%未向一个或多个性伴侣透露其 HIV 状况,38%报告与最近的性伴侣发生过无保护性行为。酒精使用障碍的患病率很高(54%),38%报告在过去一年中使用过毒品。中度至重度药物使用显著降低了实现病毒抑制的几率(调整后的优势比为 0.69;95%置信区间:0.48-0.98)。
我们的研究结果强调了在 HIV 护理中需要综合治疗物质障碍,以提高秘鲁利马 TGW 的病毒抑制率。