Department of Thoracic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Graduate School of Anhui University of Chinese Medicine, Hefei, China.
Thorac Cancer. 2019 Apr;10(4):898-903. doi: 10.1111/1759-7714.13021. Epub 2019 Mar 15.
In this study, we investigated the relationship between chronic cough and clinicopathological features in postoperative patients with non-small cell lung cancer (NSCLC) and evaluated the effectiveness of acupuncture therapy for the treatment of postoperative chronic cough in patients with NSCLC.
We retrospectively evaluated 171 patients with NSCLC who received lobectomy at our center between September 2017 and February 2018. The Mandarin Chinese version of the Leicester Cough Questionnaire (LCQ-MC) was used to evaluate the degree of cough in patients. Postoperative cough was assessed by a visual analog scale (VAS).
The total LCQ-MC score for the whole group was 19.79 ± 0.53 before surgery and 18.40 ± 0.70 after surgery (p < 0.001). Logistic regression analysis showed that right lung cancer, difficult airway, acute cough and history of COPD were independent predictors of chronic cough. Of the 68 patients diagnosed with chronic cough, 41 received acupuncture therapy (acupuncture therapy group), and 27 received no acupuncture therapy (no therapy group). No significant difference was found between the two groups in terms of their LCQ-MC scores at eight weeks after surgery (p = 0.756). However, the acupuncture therapy group had a significantly higher LCQ-MC score than the no therapy group at 10 weeks after surgery (p = 0.002).
Right lung cancer, difficult airway, acute cough, and history of COPD are independent predictors of chronic cough after surgery. For patients with chronic cough, acupuncture therapy can shorten the recovery time and improve quality of life after surgery.
本研究旨在探讨非小细胞肺癌（NSCLC）术后患者慢性咳嗽与临床病理特征的关系，并评估针刺疗法治疗 NSCLC 术后慢性咳嗽的疗效。
回顾性分析 2017 年 9 月至 2018 年 2 月在我院行肺叶切除术的 171 例 NSCLC 患者。采用莱斯特咳嗽问卷中文简体版（LCQ-MC）评估患者咳嗽程度，采用视觉模拟评分（VAS）评估术后咳嗽。
全组患者术前 LCQ-MC 总分为 19.79±0.53，术后为 18.40±0.70（p<0.001）。Logistic 回归分析显示，右肺癌、困难气道、急性咳嗽和 COPD 病史是慢性咳嗽的独立预测因素。68 例诊断为慢性咳嗽的患者中，41 例接受针刺治疗（针刺治疗组），27 例未接受针刺治疗（无治疗组）。两组患者术后 8 周 LCQ-MC 评分无统计学差异（p=0.756），但术后 10 周针刺治疗组 LCQ-MC 评分明显高于无治疗组（p=0.002）。
右肺癌、困难气道、急性咳嗽和 COPD 病史是术后慢性咳嗽的独立预测因素。对于慢性咳嗽患者，针刺疗法可缩短术后恢复时间，提高生活质量。
