Zhang Rong, Yang Xuan, He Tao, Men Bo, Nian Zi-Xiong, Yu Jie, Zhang Yi-Fan, Liu Xing-Kai, Zhang Xin, He Gong-Hao, Cai Wen-Ke
Department of Cardiothoracic Vascular Surgery, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, China.
Department of Respiratory and Critical Care, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, China
BMJ Open. 2025 Jun 30;15(6):e096934. doi: 10.1136/bmjopen-2024-096934.
Previous studies have pointed out that persistent cough is a common complication after pulmonary resection and its occurrence is closely related to inflammatory response. However, there are no clinical studies to date that directly verify that the use of non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the incidence of persistent cough after pulmonary resection (CAP). In view of this, this study aimed to explore and confirm whether exposure to NSAIDs can effectively reduce the incidence of CAP through a prospective cohort study.
We will conduct a single-centre, prospective cohort comparative study to investigate the impact of NSAIDs use on persistent cough after video-assisted thoracoscopic (VATS) lung resection surgery. The study will include all patients without preoperative cough symptoms who are scheduled for VATS lung resection. These patients will be divided into exposed and non-exposed groups according to whether they used NSAIDs after surgery. The primary outcome measures of this study are the incidence of CAP and the association between NSAIDs exposure and the incidence of CAP in patients undergoing VATS lung resection, while the secondary outcome parameter was set as severity of cough.
This research was approved by the Ethics Committee of the 920th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army (2024-041-01). The study findings will be published in peer-reviewed journals and presented at professional conferences.
NCT06476249.
既往研究指出，持续性咳嗽是肺切除术后的常见并发症，其发生与炎症反应密切相关。然而，迄今为止尚无临床研究直接证实使用非甾体类抗炎药（NSAIDs）可降低肺切除术后持续性咳嗽（CAP）的发生率。鉴于此，本研究旨在通过一项前瞻性队列研究探索并证实接触NSAIDs是否能有效降低CAP的发生率。
我们将进行一项单中心、前瞻性队列对比研究，以调查使用NSAIDs对电视辅助胸腔镜（VATS）肺切除术后持续性咳嗽的影响。该研究将纳入所有计划接受VATS肺切除且术前无咳嗽症状的患者。这些患者将根据术后是否使用NSAIDs分为暴露组和非暴露组。本研究的主要结局指标是CAP的发生率以及VATS肺切除患者中NSAIDs暴露与CAP发生率之间的关联，而次要结局参数设定为咳嗽严重程度。
本研究已获得中国人民解放军联勤保障部队第九二〇医院伦理委员会批准（2024-041-01）。研究结果将发表在同行评审期刊上，并在专业会议上展示。
NCT06476249。
