Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905, United States.
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, United States.
Curr Opin Biotechnol. 2019 Oct;59:55-64. doi: 10.1016/j.copbio.2019.02.006. Epub 2019 Mar 12.
Going forward, industrial biotechnology must consider non-model metabolic engineering platforms if it is to have maximal impact. This will include microorganisms that natively possess strategic physiological and metabolic features but lack either molecular genetic tools or such tools are rudimentary, requiring further development. If non-model platforms are successfully deployed, new avenues for production of fuels and chemicals from renewable feedstocks or waste materials will emerge. Here, the challenges and opportunities for extreme thermophiles as metabolic engineering platforms are discussed.
展望未来，如果工业生物技术要产生最大的影响，就必须考虑非模型代谢工程平台。这将包括那些天然具有战略生理和代谢特征的微生物，但缺乏分子遗传工具，或者工具还很基础，需要进一步开发。如果非模型平台能够成功部署，那么利用可再生原料或废物生产燃料和化学品的新途径将会出现。在这里，讨论了极端嗜热菌作为代谢工程平台的挑战和机遇。
