Institute of Biochemical Engineering, Technische Universität Braunschweig, Gaußstraße 17, 38106 Braunschweig, Germany.
Curr Opin Biotechnol. 2012 Aug;23(4):631-40. doi: 10.1016/j.copbio.2011.11.012. Epub 2011 Dec 2.
Since their discovery almost 60 years ago, Corynebacterium glutamicum and related subspecies are writing a remarkable success story in industrial biotechnology. Today, these gram-positive soil bacteria, traditionally well-known as excellent producers of L-amino acids are becoming flexible, efficient production platforms for various chemicals, materials and fuels. This development is intensively driven by systems metabolic engineering concepts integrating systems biology and synthetic biology into strain engineering.
自近 60 年前发现以来,谷氨酸棒杆菌及其相关亚种在工业生物技术领域谱写了一段非凡的成功故事。如今,这些革兰氏阳性土壤细菌,传统上以生产 L-氨基酸而闻名,正在成为各种化学品、材料和燃料的灵活、高效的生产平台。这一发展是由系统代谢工程概念推动的,该概念将系统生物学和合成生物学整合到菌株工程中。