Massachusetts General Hospital, Department of Psychiatry, Dauten Family Center for Bipolar Treatment Innovation, 50 Staniford Street, Suite 580, Boston, MA 02114, United States; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, United States.
Massachusetts General Hospital, Department of Psychiatry, Dauten Family Center for Bipolar Treatment Innovation, 50 Staniford Street, Suite 580, Boston, MA 02114, United States.
J Affect Disord. 2019 May 1;250:278-283. doi: 10.1016/j.jad.2019.03.033. Epub 2019 Mar 6.
Individuals with bipolar disorder (BD) are more likely than the general population to develop risk factors associated with cardiovascular disease, one of the leading causes of morbidity and mortality in this clinical population. To address this disproportionate medical burden, we developed Nutrition Exercise and Wellness Treatment (NEW Tx), a lifestyle intervention for individuals with BD.
In this study, participants were randomized to NEW Tx (n = 19) or a treatment as usual waitlist (n = 19). We examine the intervention's efficacy to improve the physical and psychological outcomes of individuals with BD. Assessors were blind to participant condition throughout study duration.
The NEW Tx group reported increased weekly exercise duration and overall functioning, and decreased depression and illness severity over the study duration. However, only improvements in functioning were significantly greater in the NEW Tx group than in the control group. There were no group differences in weight loss or mood symptoms over the study duration.
Limitations to this study include lack of objective measurement of exercise and a small and relatively homogeneous sample.
These data suggest that a manualized lifestyle intervention for BD may not be ideal to improve lifestyle changes in this clinical population. Further research is needed to pilot personalized approaches to creating a healthy lifestyle in BD.
双相情感障碍 (BD) 患者比一般人群更容易出现与心血管疾病相关的风险因素，心血管疾病是该临床人群发病率和死亡率的主要原因之一。为了应对这种不成比例的医疗负担，我们开发了营养运动与健康治疗 (NEW Tx)，这是一种针对 BD 患者的生活方式干预措施。
在这项研究中，参与者被随机分配到 NEW Tx（n=19）或常规治疗等待名单（n=19）。我们研究了干预措施对改善 BD 患者身体和心理结果的疗效。评估人员在整个研究期间对参与者的状况保持盲态。
在研究期间，NEW Tx 组报告每周运动时间增加，整体功能改善，抑郁和疾病严重程度降低。然而，只有在 NEW Tx 组，功能改善的程度显著大于对照组。在研究期间，体重减轻或情绪症状在两组之间没有差异。
本研究的局限性包括缺乏对运动的客观测量以及样本量小且相对同质。
这些数据表明，针对 BD 的标准化生活方式干预可能并不理想，无法改善该临床人群的生活方式改变。需要进一步研究，以探索个性化方法在 BD 中创建健康生活方式。
