School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
Institute of Food Safety and Health Risk Assessment, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan.
Nutrients. 2019 Mar 14;11(3):629. doi: 10.3390/nu11030629.
has a long history of use worldwide as a food and in folk medicine. In this study, we aimed to investigate the effect of an aqueous extract of leaves (HC) on type 2 diabetes mellitus (T2DM). Two types of animal models were used in this study: Streptozotocin (STZ)-induced T2DM (Wistar rats; = 8) and C57BKSdb/db mice ( = 5). After treatment with HC for 28 days, glucose tolerance improved in both of the diabetic animal models. As significant effects were shown after 14 days of treatment in the STZ-induced T2DM model, we carried out the experiments with it. After 28 days of treatment with HC, the levels of cholesterol, triglyceride, high-density lipoprotein, and low-density lipoprotein were significantly improved in the STZ-induced T2DM model. The lesions degree of islet β-cells was decreased after the HC treatment. Although the insulin level increased moderately, the aldosterone level was significantly decreased in the HC-treated groups, suggesting that aldosterone might play an important role in this effect. In summary, HC is a natural product and it is worth exploring its effect on T2DM.
在全球范围内， 叶子已有悠久的食用和民间药用历史。在这项研究中，我们旨在研究 叶子的水提物（HC）对 2 型糖尿病（T2DM）的影响。本研究使用了两种动物模型：链脲佐菌素（STZ）诱导的 T2DM（Wistar 大鼠；n = 8）和 C57BKSdb/db 小鼠（n = 5）。用 HC 治疗 28 天后，两种糖尿病动物模型的葡萄糖耐量均得到改善。由于在 STZ 诱导的 T2DM 模型中，治疗 14 天后就显示出显著效果，因此我们对其进行了实验。用 HC 治疗 28 天后，STZ 诱导的 T2DM 模型中的胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白水平显著改善。HC 治疗后胰岛 β 细胞的病变程度降低。尽管胰岛素水平适度增加，但 HC 治疗组的醛固酮水平显著降低，表明醛固酮可能在这种作用中起重要作用。总之，HC 是一种天然产物，值得探索其对 T2DM 的作用。
