Haas H, Morris J F, Samson S
Clin Ther. 1986;8(3):301-8.
A double-blind, randomized, placebo-controlled trial was undertaken to evaluate the effect of penicillin on the pneumococcal carrier state of 32 men with chronic bronchitis. Treatment consisted of 250-mg phenoxymethyl penicillin or placebo tablets taken by mouth twice daily for periods of one to three years. Penicillin eradicated Streptococcus pneumoniae from the respiratory tracts of all carriers and prevented colonization with pneumococci for the duration of treatment, whereas placebo had no discernible effect on the carrier state (P = 0.0015). The conclusion is that daily penicillin orally in low doses eliminates pneumococci from the oropharynx of elderly patients with clinically stable chronic bronchitis.
开展了一项双盲、随机、安慰剂对照试验，以评估青霉素对32名慢性支气管炎男性患者肺炎球菌携带状态的影响。治疗方法为口服250毫克苯氧甲基青霉素或安慰剂片，每日两次，持续一至三年。青霉素清除了所有携带者呼吸道中的肺炎链球菌，并在治疗期间预防了肺炎球菌的定植，而安慰剂对携带状态没有明显影响（P = 0.0015）。结论是，每日口服低剂量青霉素可消除临床稳定的老年慢性支气管炎患者口咽部的肺炎球菌。
