Ewing Altovise T, Kalu Nnenna, Cain Gloria, Erby Lori H, Ricks-Santi Luisel J, Tetteyfio-Kidd Telemaque Eva, Scott Denise M
23andMe Inc., Mountain View, CA, USA.
College of Medicine Alcohol Research Center, Howard University, Washington, DC, USA.
J Community Genet. 2019 Oct;10(4):471-480. doi: 10.1007/s12687-019-00411-0. Epub 2019 Mar 14.
This study evaluated factors associated with willingness to provide biospecimens for cancer genetic research among African American cancer survivors. A total of 200 African American adults diagnosed with breast, colon, and/or prostate cancers completed a self-administered survey. Family history information, beliefs about cancer research, cancer genetics and disparities knowledge, willingness to provide a biospecimen, and demographics were obtained. Chi-square, independent samples t tests, and logistic regression analyses were performed. Overall, 79% of this sample was willing to provide a biospecimen for cancer genetics research. Independent associations of willingness to provide a biospecimen existed among demographics (males (p = 0.041)), those who believed in the importance of genetic causes of cancer (p < 0.001), individuals who believe it is important to participate in genetics research (p < 0.001), and those who indicated they would participate in genetics research to help future generations (p = 0.026). Overall, 12.5-56% of participants demonstrated some level of genetics and cancer disparities. This study identified factors that may be incorporated into future research interventions to engage the African American cancer population in cancer genetics biobanking research.
本研究评估了非裔美国癌症幸存者中与愿意为癌症基因研究提供生物样本相关的因素。共有200名被诊断患有乳腺癌、结肠癌和/或前列腺癌的非裔美国成年人完成了一项自填式调查。获取了家族史信息、对癌症研究的看法、癌症遗传学和差异知识、提供生物样本的意愿以及人口统计学信息。进行了卡方检验、独立样本t检验和逻辑回归分析。总体而言，该样本中有79%愿意为癌症基因研究提供生物样本。在人口统计学特征（男性（p = 0.041））、那些认为癌症基因病因很重要的人（p < 0.001）、认为参与基因研究很重要的个体（p < 0.001）以及那些表示会参与基因研究以帮助后代的人（p = 0.026）中，存在提供生物样本意愿的独立关联。总体而言，12.5%至56%的参与者表现出一定程度的遗传学和癌症差异知识。本研究确定了一些因素，这些因素可纳入未来的研究干预措施，以使非裔美国癌症患者群体参与癌症基因生物样本库研究。
