Himes Deborah O, Davis Sarah H, Lassetter Jane H, Peterson Neil E, Clayton Margaret F, Birmingham Wendy C, Kinney Anita Y
College of Nursing, Brigham Young University, 500 Spencer W. Kimball Tower, Provo, UT, USA.
College of Nursing, University of Utah, 10 South 2000 East, Salt Lake City, UT, 84112, USA.
J Community Genet. 2019 Oct;10(4):481-487. doi: 10.1007/s12687-019-00413-y. Epub 2019 Mar 15.
Knowledge of breast cancer genetics is critical for those at increased hereditary risk who must make decisions about breast cancer screening options. This descriptive study explored theory-based relationships among cognitive and emotional variables related to knowledge of breast cancer genetics in cancer families. Participants included first-degree relatives of women with breast cancer who had received genetic counseling and testing. Study participants themselves did not have breast cancer and had not received genetic counseling or testing. Data were collected by telephone interviews and surveys. Variables analyzed included numeracy, health literacy, cancer-related distress, age, education, and the reported amount of information shared by the participants' family members about genetic counseling. The multiple regression model explained 13.9% of variance in knowledge of breast cancer genetics (p = 0.03). Best fit of the multiple regression model included all variables except education. Reported amount of information shared was the only independently significant factor associated with knowledge (β = 0.28, p = 0.01). Participants who reported higher levels of information shared by a family member about information learned during a genetic counseling session also demonstrated increased knowledge about breast cancer genetics.
对于那些具有较高遗传风险、必须就乳腺癌筛查选项做出决策的人来说，了解乳腺癌遗传学至关重要。这项描述性研究探讨了癌症家族中与乳腺癌遗传学知识相关的认知和情感变量之间基于理论的关系。参与者包括接受过遗传咨询和检测的乳腺癌女性的一级亲属。研究参与者本人没有患乳腺癌，也没有接受过遗传咨询或检测。数据通过电话访谈和调查收集。分析的变量包括算术能力、健康素养、癌症相关困扰、年龄、教育程度，以及参与者家庭成员报告的关于遗传咨询的信息共享量。多元回归模型解释了乳腺癌遗传学知识中13.9%的方差变异（p = 0.03）。多元回归模型的最佳拟合包括除教育程度之外的所有变量。报告的信息共享量是与知识相关的唯一独立显著因素（β = 0.28，p = 0.01）。那些报告家庭成员分享了更多关于在遗传咨询过程中学到的信息的参与者，对乳腺癌遗传学的了解也更多。
