氢过氧脂肪酸使网织红细胞脂氧合酶失活，且与氢过氧化物酶反应无关。
Hydroperoxyfatty acids inactivate the reticulocyte lipoxygenase independently of a hydroperoxidase reaction.
作者信息
Rapoport S, Härtel B, Schewe T, Kühn H
出版信息
FEBS Lett. 1986 Jul 7;202(2):202-6. doi: 10.1016/0014-5793(86)80687-1.
PMID:3087777
Abstract
From a comparison of 9Ds-HPODE and 13Ls-HPODE and their methyl esters as substrates and inactivating agents of reticulocyte lipoxygenase it is concluded that the compounds inactivate the enzyme independently of any hydroperoxidase reaction. The protective effect of 4-nitrocatechol indicates the formation of Fe(III) complexes of the enzyme with the hydroperoxyfatty acid compounds prior to inactivation.
摘要
通过比较9Ds-HPODE和13Ls-HPODE及其甲酯作为网织红细胞脂氧合酶的底物和失活剂，得出这些化合物使该酶失活的过程与任何氢过氧化物酶反应无关的结论。4-硝基邻苯二酚的保护作用表明，在酶失活之前，酶与氢过氧化脂肪酸化合物形成了Fe(III)络合物。
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