HLA - B8和HLA - DR3阳性个体中自然杀伤细胞细胞毒性升高。

Elevated natural killer cytotoxicity in HLA-B8 and HLA-DR3-positive individuals.

作者信息

Jakobisiak M, Saidman S, Schlaut J, Pazderka F, Dossetor J B

出版信息

Immunol Lett. 1986 Mar;12(2-3):61-3. doi: 10.1016/0165-2478(86)90083-0.

Abstract

Increased natural killer cytotoxicity in persons positive for HLA-B8 and HLA-DR3 has been found. It is suggested that linkage disequilibrium between the genes coding for HLA-B8 and HLA-DR3 may have evolved as a result of strengthened immunological surveillance in individuals bearing them, as decrease in the frequency of both these antigens has recently been reported in patients with tumours.

摘要

已发现HLA - B8和HLA - DR3阳性者的自然杀伤细胞细胞毒性增加。有人提出，编码HLA - B8和HLA - DR3的基因之间的连锁不平衡可能是由于携带这些基因的个体免疫监视增强而进化形成的，因为最近在肿瘤患者中报道了这两种抗原的频率均有所下降。