Mueller-Eckhardt C, Mueller-Eckhardt G, Willen-Ohff H, Horz A, Küenzlen E, O'Neill G J, Schendel D J
Tissue Antigens. 1985 Jul;26(1):71-6. doi: 10.1111/j.1399-0039.1985.tb00936.x.
In a prospective study the immunogenicity of the Zwa antigen during gestation was investigated. Twenty-six out of 1,211 pregnant women were Zwa negative (2.15%). In 2 out of 23 Zwa negative mothers who delivered Zwa positive children, an antibody to Zwa was detected. To determine the relationship between the immune response of pregnant women towards Zwa and the MHC, the phenotype frequencies of HLA-A, B, C, DR, and complement BF, C2, C4A, C4B allotypes of "non-responders" without detectable Zwa antibodies (N = 20) were compared with a group of "responders", i.e. Zwa negative mothers giving birth to Zwa positive children with typical neonatal alloimmune thrombocytopenia (NAIT; N = 39) and with a normal control population. When compared to the normal control group, "non-responders" showed a significant increase of the DRw6 frequency, whereas in the "responders" group HLA-A1, B8, DR3, and C4A*QO were significantly elevated. If "non-responders" and "responders" were directly compared, only B8 and DR3 remained significantly different. The strongest association with a hypothetical immune response gene appeared to exist with DR3.
在一项前瞻性研究中，对妊娠期间Zwa抗原的免疫原性进行了调查。1211名孕妇中有26名Zwa阴性（2.15%）。在23名Zwa阴性母亲中，有2名产下Zwa阳性孩子的母亲检测到了Zwa抗体。为了确定孕妇对Zwa的免疫反应与主要组织相容性复合体（MHC）之间的关系，将未检测到Zwa抗体的“无反应者”（N = 20）的HLA - A、B、C、DR以及补体BF、C2、C4A、C4B同种异型的表型频率，与一组“有反应者”进行比较，“有反应者”即产下患有典型新生儿同种免疫性血小板减少症（NAIT）的Zwa阳性孩子的Zwa阴性母亲（N = 39）以及正常对照组。与正常对照组相比，“无反应者”的DRw6频率显著增加，而在“有反应者”组中，HLA - A1、B8、DR3和C4A*QO显著升高。如果直接比较“无反应者”和“有反应者”，只有B8和DR3仍存在显著差异。与假设的免疫反应基因的最强关联似乎存在于DR3。
