Porges A, Bussel J, Kimberly R, Schulman I, Pollack M, Pandey J, Barandun S, Hilgartner M
Tissue Antigens. 1985 Aug;26(2):132-7. doi: 10.1111/j.1399-0039.1985.tb00945.x.
The HLA type DR3 was present in 11 of 26 patients with Chronic Idiopathic Thrombocytopenic Purpura (ITP), a significantly increased frequency (p less than 0.05). Levels of platelet associated immunoglobulin M(PAIgM) were significantly higher in the B8 and/or DR3 positive group of chronic ITP patients than in the B8 DR3 negative patients despite similar clinical outcomes. Other immunologic parameters assessed, including serum immunoglobulin levels, rate of catabolism of transfused IgG, and antibody coated autologous red cell clearances were similar for both groups. These results suggest that there is an immunobiologic abnormality associated with the B8 DR3 allotypes which may result in a predisposition not only to chronic ITP, but also to a significant increase in PAIgM. These results are in accord with studies linking autoantibody with B8 DR3.
26例慢性特发性血小板减少性紫癜（ITP）患者中有11例存在HLA - DR3型，频率显著增加（p小于0.05）。尽管临床结果相似，但慢性ITP患者中B8和/或DR3阳性组的血小板相关免疫球蛋白M（PAIgM）水平明显高于B8 DR3阴性患者。两组评估的其他免疫参数，包括血清免疫球蛋白水平、输注IgG的分解代谢率和抗体包被的自体红细胞清除率相似。这些结果表明，存在与B8 DR3同种异型相关的免疫生物学异常，这可能不仅导致慢性ITP的易感性增加，还会导致PAIgM显著增加。这些结果与将自身抗体与B8 DR3联系起来的研究一致。
