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通过用活的脑膜炎奈瑟菌免疫小鼠所证实的一种常见奈瑟菌抗原。

A common neisserial antigen evidenced by immunization of mice with live Neisseria meningitidis.

作者信息

Martin P M, Lavitola A, Aoun L, Ancelle R, Cremieux A C, Riou J Y

出版信息

Infect Immun. 1986 Jul;53(1):229-33. doi: 10.1128/iai.53.1.229-233.1986.

DOI:10.1128/iai.53.1.229-233.1986
PMID:3087882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC260102/
Abstract

Mice immunized with live meningococci developed antibodies directed against various antigens of Neisseria gonorrhoeae and Neisseria meningitidis, as demonstrated by immunoblotting. An antigen of 70 kilodaltons appeared to be common and stable in all gonococcal strains tested and highly immunogenic in mice infected with N. meningitidis.

摘要

如免疫印迹所示，用活的脑膜炎球菌免疫的小鼠产生了针对淋病奈瑟菌和脑膜炎奈瑟菌各种抗原的抗体。一种70千道尔顿的抗原在所有测试的淋球菌菌株中似乎是常见且稳定的，并且在感染脑膜炎奈瑟菌的小鼠中具有高度免疫原性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/267c/260102/2c04adabb424/iai00100-0239-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/267c/260102/c232ae1a5449/iai00100-0238-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/267c/260102/846dc25c0498/iai00100-0239-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/267c/260102/2c04adabb424/iai00100-0239-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/267c/260102/c232ae1a5449/iai00100-0238-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/267c/260102/846dc25c0498/iai00100-0239-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/267c/260102/2c04adabb424/iai00100-0239-b.jpg

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Infect Immun. 1986 Jul;53(1):229-33. doi: 10.1128/iai.53.1.229-233.1986.
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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Typing of non-serogroupable Neisseria meningitidis by means of sensitivity to R-type pyocines of Pseudomonas aeruginosa.
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Gonococcal salpingitis is less likely to recur with Neisseria gonorrhoeae of the same principal outer membrane protein antigenic type.由具有相同主要外膜蛋白抗原类型的淋病奈瑟菌引起的淋菌性输卵管炎复发的可能性较小。
Am J Obstet Gynecol. 1980 Dec 1;138(7 Pt 2):978-80. doi: 10.1016/0002-9378(80)91091-1.
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A study by high-resolution two-dimensional polyacrylamide gel electrophoresis of relationships between Neisseria gonorrhoeae and other bacteria.一项通过高分辨率二维聚丙烯酰胺凝胶电泳对淋病奈瑟菌与其他细菌之间关系的研究。
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IgA protease of Neisseria gonorrhoeae: isolation and characterization of the gene and its extracellular product.淋病奈瑟菌的IgA蛋白酶：基因及其细胞外产物的分离与特性分析
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Use of a zwitterionic detergent for the restoration of the antibody-binding capacity of electroblotted meningococcal outer membrane proteins.使用两性离子去污剂恢复电印迹脑膜炎球菌外膜蛋白的抗体结合能力。
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Monoclonal antibody that recognizes an outer membrane antigen common to the pathogenic Neisseria species but not to most nonpathogenic Neisseria species.一种单克隆抗体，可识别致病性奈瑟菌属共有的外膜抗原，但大多数非致病性奈瑟菌属不具有该抗原。
Infect Immun. 1984 Mar;43(3):994-9. doi: 10.1128/iai.43.3.994-999.1984.
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Induction of serum resistance in recent isolates of Neisseria gonorrhoeae by a low-molecular-weight fraction of guinea pig serum.豚鼠血清低分子量组分诱导淋病奈瑟菌近期分离株产生血清抗性。
J Infect Dis. 1983 Aug;148(2):334. doi: 10.1093/infdis/148.2.334.
10
Nucleotide sequence homology between the immunoglobulin A1 protease genes of Neisseria gonorrhoeae, Neisseria meningitidis, and Haemophilus influenzae.淋病奈瑟菌、脑膜炎奈瑟菌和流感嗜血杆菌免疫球蛋白A1蛋白酶基因之间的核苷酸序列同源性。
Infect Immun. 1984 Jan;43(1):101-7. doi: 10.1128/iai.43.1.101-107.1984.