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淋病奈瑟菌、脑膜炎奈瑟菌和流感嗜血杆菌免疫球蛋白A1蛋白酶基因之间的核苷酸序列同源性。

Nucleotide sequence homology between the immunoglobulin A1 protease genes of Neisseria gonorrhoeae, Neisseria meningitidis, and Haemophilus influenzae.

作者信息

Koomey J M, Falkow S

出版信息

Infect Immun. 1984 Jan;43(1):101-7. doi: 10.1128/iai.43.1.101-107.1984.

DOI:10.1128/iai.43.1.101-107.1984
PMID:6317561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC263394/
Abstract

Isolated DNA fragments encoding the immunoglobulin A1 (IgA1) protease of Neisseria gonorrhoeae were used as hybridization probes to search for homologous sequences in whole cell DNA from Neisseria meningitidis and Haemophilus influenzae. Significant homology was detected. That the detected homology represented IgA1 protease-specific sequences was confirmed by the cloning of these sequences in Escherichia coli HB101 and demonstrating the expression of IgA1 protease by these transformed cells. Molecular probing of commensal Neisseria and Haemophilus species, which do not elaborate IgA1 protease activity, revealed that they were devoid of sequence homology with the cloned IgA1 protease gene DNA.

摘要

编码淋病奈瑟菌免疫球蛋白A1（IgA1）蛋白酶的分离DNA片段被用作杂交探针，以在脑膜炎奈瑟菌和流感嗜血杆菌的全细胞DNA中寻找同源序列。检测到显著的同源性。通过将这些序列克隆到大肠杆菌HB101中并证明这些转化细胞表达IgA1蛋白酶，证实了检测到的同源性代表IgA1蛋白酶特异性序列。对不产生IgA1蛋白酶活性的共生奈瑟菌和嗜血杆菌物种进行分子探测，发现它们与克隆的IgA1蛋白酶基因DNA没有序列同源性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/142e/263394/4b64ae61a6e4/iai00130-0126-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/142e/263394/1befa697799b/iai00130-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/142e/263394/a6fce684219c/iai00130-0125-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/142e/263394/4b64ae61a6e4/iai00130-0126-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/142e/263394/1befa697799b/iai00130-0124-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/142e/263394/a6fce684219c/iai00130-0125-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/142e/263394/4b64ae61a6e4/iai00130-0126-a.jpg

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