Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA.
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Apoptosis. 2019 Jun;24(5-6):529-537. doi: 10.1007/s10495-019-01531-1.
Although new cancer therapeutics are discovered at a rapid pace, lack of effective means of delivery and cancer chemoresistance thwart many of the promising therapeutics. We demonstrate a method that confronts both of these issues with the light-activated delivery of a Bcl-2 functional converting peptide, NuBCP-9, using hollow gold nanoshells. This approach has shown not only to increase the efficacy of the peptide 30-fold in vitro but also has shown to reduce paclitaxel resistant H460 lung xenograft tumor growth by 56.4%.
尽管新的癌症治疗方法正在快速被发现，但缺乏有效的传递手段和癌症化疗耐药性使许多有前途的治疗方法受阻。我们展示了一种使用中空金纳米壳用光激活传递 Bcl-2 功能转化肽 NuBCP-9 的方法来应对这两个问题。这种方法不仅显示出在体外使肽的功效提高了 30 倍，而且还显示出将紫杉醇耐药的 H460 肺异种移植肿瘤生长减少了 56.4%。
