Young Megan K, Cripps Allan W, Nimmo Graeme R
School of Medicine and Menzies Health Institute Queensland, Griffith University - Metro North Public Health Unit, Metro North Hospital and Health Service
Commun Dis Intell (2018). 2019 Mar 15;43. doi: 10.33321/cdi.2019.43.9.
Objective To describe the use of normal human immunoglobulin (NHIG) recommended for public health purposes in Queensland and Australia. Methods Queensland public health unit (PHU) data on notified cases of measles, rubella and hepatitis A from 2004 to 2014 were examined; particularly regarding the number of contacts offered NHIG and the volume recommended per contact. The National Blood Authority (NBA) provided unidentified data from NHIG order form inception (June 2014) through December 2016. Queensland orders were compared to PHU data where the data timeframes overlapped. Results NHIG usage varied by condition. For hepatitis A, usage declined after the introduction of vaccination for contacts in 2010. Usage fluctuated across the study period for measles and was not recommended for rubella. Average volumes per contact for hepatitis A and measles were 1.6mL and 11.9mL respectively based on PHU data. PHU data approximated NBA data on NHIG usage for hepatitis A and rubella contacts. Calculated volumes of NHIG per measles contact were also similar, but PHU data underestimated the number of measles contacts for whom NHIG was ordered. Discussion This study is the first to document the use of NHIG for public health purposes in Australia. Results will be valuable for national blood sufficiency planning and cost effectiveness studies in the event of alterations to NHIG dosage recommendations.
目的 描述在昆士兰州和澳大利亚为公共卫生目的推荐使用的正常人免疫球蛋白（NHIG）的情况。方法 对昆士兰州公共卫生单位（PHU）2004年至2014年麻疹、风疹和甲型肝炎通报病例的数据进行了审查；特别关注接受NHIG的接触者数量以及每次接触推荐的剂量。国家血液管理局（NBA）提供了从NHIG订单表格启用（2014年6月）到2016年12月的未识别数据。将昆士兰州的订单与数据时间范围重叠的PHU数据进行了比较。结果 NHIG的使用因疾病而异。对于甲型肝炎，2010年为接触者引入疫苗接种后使用量下降。在整个研究期间，麻疹的使用量波动，风疹则不推荐使用。根据PHU数据，甲型肝炎和麻疹每次接触的平均剂量分别为1.6毫升和11.9毫升。PHU数据与NBA关于甲型肝炎和风疹接触者NHIG使用情况的数据相近。计算得出的每次麻疹接触者的NHIG剂量也相似，但PHU数据低估了订购NHIG的麻疹接触者数量。讨论 本研究首次记录了在澳大利亚为公共卫生目的使用NHIG的情况。如果NHIG剂量建议发生变化，研究结果对于国家血液充足性规划和成本效益研究将具有重要价值。
