Ismaeel N, el-Moug T, Furr J R, Russell A D
J Appl Bacteriol. 1986 Apr;60(4):361-7. doi: 10.1111/j.1365-2672.1986.tb01744.x.
Spheroplasts of three strains of Providencia stuartii (one sensitive, one moderately sensitive and one resistant to chlorhexidine) were induced by cefoxitin, glycine or a lysozyme-tris-EDTA combination, and their susceptibility to chlorhexidine-induced lysis investigated. Maximum lysis of spheroplasts occurred at a low (2.5-5 micrograms/ml) concentration of chlorhexidine and was greatest with the most sensitive strain, Pv2. The possible role of the inner membrane in chlorhexidine resistance is considered in the light of the findings obtained.
用头孢西丁、甘氨酸或溶菌酶 - 三羟甲基氨基甲烷 - 乙二胺四乙酸组合诱导了三种斯氏普罗威登斯菌菌株（一株对洗必泰敏感，一株中度敏感，一株对洗必泰耐药）的原生质球，并研究了它们对洗必泰诱导裂解的敏感性。原生质球在低浓度（2.5 - 5微克/毫升）的洗必泰作用下发生最大程度的裂解，且最敏感的菌株Pv2的裂解程度最大。根据所获得的研究结果，探讨了内膜在洗必泰耐药性中可能发挥的作用。
