Chawner J A, Gilbert P
Department of Pharmacy, University of Manchester, UK.
J Appl Bacteriol. 1989 Mar;66(3):253-8. doi: 10.1111/j.1365-2672.1989.tb02476.x.
Strains of Providencia stuartii with demonstrated resistance towards chlorhexidine did not show such resistance towards either of the related biguanide antiseptics, alexidine or vantocil. Alexidine promoted a significantly faster alteration in the permeability of Escherichia coli cell membranes towards various metal cations than chlorhexidine. Differential thermal analysis of various mixed lipid vesicles and pure phospholipid vesicles showed alexidine to share with vantocil the property of producing lipid phase separation and domain formation. It is suggested that the nature of the end-group on the biguanides affects the ability to produce lipid domains in cell membranes and this this might, in turn, affect activity and resistance patterns observed.
已证明对洗必泰具有抗性的斯氏普罗威登斯菌菌株，对相关的双胍类防腐剂（阿来西定或凡托西）均未表现出这种抗性。与洗必泰相比，阿来西定能显著更快地改变大肠杆菌细胞膜对各种金属阳离子的通透性。对各种混合脂质囊泡和纯磷脂囊泡的差示热分析表明，阿来西定与凡托西具有产生脂质相分离和结构域形成的特性。有人认为，双胍类药物端基的性质会影响在细胞膜中产生脂质结构域的能力，而这反过来可能会影响所观察到的活性和抗性模式。
