Yuan Shi-Min
Department of Cardiothoracic Surgery, The First Hospital of Putian, Teaching Hospital, Fujian Medical University, Putian, Fujian Province, China.
J Matern Fetal Neonatal Med. 2020 Aug;33(15):2671-2678. doi: 10.1080/14767058.2018.1555804. Epub 2019 Mar 18.
Fetal arrhythmias are common, and they may resolve spontaneously in majority of the cases. Sustained fetal arrhythmias associated with major structural heart disorders, hydrops fetalis, and fetal heart failure warrant intrauterine pharmaceutical conversion of heart rhythm or early pacemaker implant in order to avoid fetal demise. Fetal atrial flutter (AF) and supraventricular tachycardia (SVT) resemble in terms of the effects of intrauterine therapies. Digoxin is more suitable for rhythm conversion of fetal AF and SVT in fetuses free of hydrops fetalis, while sotalol shows better effects for those with hydrops fetalis. In fetal cases of atrioventricular blocks, an etiological treatment for the maternal antibody exposure by steroids could be an alternative remedy. In this article, the clinical diagnosis and treatment of fetal arrhythmias are presented, and advantages and disadvantages of antiarrhythmic agents for fetal arrhythmias are compared.
胎儿心律失常很常见,大多数情况下可能会自行缓解。与严重结构性心脏病、胎儿水肿和胎儿心力衰竭相关的持续性胎儿心律失常需要进行宫内药物心律转换或早期植入起搏器,以避免胎儿死亡。胎儿心房扑动(AF)和室上性心动过速(SVT)在宫内治疗效果方面相似。地高辛更适合于无胎儿水肿的胎儿AF和SVT的心律转换,而索他洛尔对有胎儿水肿的胎儿效果更好。在胎儿房室传导阻滞的病例中,用类固醇对母体抗体暴露进行病因治疗可能是一种替代疗法。本文介绍了胎儿心律失常的临床诊断和治疗,并比较了抗心律失常药物治疗胎儿心律失常的优缺点。