Yamamoto W S, Kirk W D
J Appl Physiol (1985). 1986 Jun;60(6):2128-34. doi: 10.1152/jappl.1986.60.6.2128.
A method is described to partition measured values of steady-state ventilatory response into an estimation of the blood flow in the respiratory controller and the sensitivity of the controller to CO2 assuming proportional control. The analysis is derived from the describing equations of a computer model and leads to the definition of a grid of lines emanating from a hypothetical reference point at negative ventilation and zero central nervous system metabolism. Data from the literature reporting differences in CO2 response among normal subjects and changes in resting ventilation and cerebral blood flow with age are reinterpreted from this perspective. Use of a structural model to interpret physiological data is shown to give a different meaning to data reduction in contrast to interpretation using statistical models like regression.
本文描述了一种方法，该方法可将稳态通气反应的测量值划分为呼吸控制器中血流的估计值以及假设为比例控制时控制器对二氧化碳的敏感性。该分析源自计算机模型的描述方程，并得出了从负通气和零中枢神经系统代谢的假设参考点发出的线网格的定义。从这个角度重新解释了文献中报告的正常受试者之间二氧化碳反应差异以及静息通气和脑血流量随年龄变化的数据。与使用回归等统计模型进行解释相比，使用结构模型来解释生理数据显示出对数据简化有不同的意义。
