皮肤白色脂肪组织：皮肤先天防御的新认识层次。

Dermal White Adipose Tissue: A Newly Recognized Layer of Skin Innate Defense.

机构信息

Department of Dermatology, University of California, San Diego, La Jolla, California, USA.

Department of Dermatology, University of California, San Diego, La Jolla, California, USA; School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.

出版信息

J Invest Dermatol. 2019 May;139(5):1002-1009. doi: 10.1016/j.jid.2018.12.031. Epub 2019 Mar 14.

DOI:10.1016/j.jid.2018.12.031

PMID:30879642

Abstract

Dermal white adipose tissue is a unique layer of adipocytes within the reticular dermis of the skin. Recently, several nonmetabolic activities have been discovered for dWAT and its fibroblast precursors. These functions include antimicrobial defense and roles in hair cycling, wound healing, and thermogenesis. In this review, we discuss recent progress in understanding the role of dermal white adipose tissue in immunity, both as an innate antimicrobial cell type and as an indirect communicator with other cutaneous immunocytes to enhance defense and potentially contribute to inflammatory disease.

摘要

真皮白色脂肪组织是皮肤网状真皮层内特有的一层脂肪细胞。最近，人们发现真皮白色脂肪组织及其成纤维前体细胞具有多种非代谢功能。这些功能包括抗菌防御以及在毛发周期、伤口愈合和产热中的作用。在这篇综述中，我们讨论了人们对真皮白色脂肪组织在免疫中的作用的理解的最新进展，包括作为先天抗菌细胞类型以及作为与其他皮肤免疫细胞的间接通讯者来增强防御并可能导致炎症性疾病的作用。