Martins Laurentino Ana Olívia, Durante de Medeiros Fabiana, de Oliveira Juliana, da Rosa Naiana, Mateus Gomes Tamires, de Medeiros Peretti Eduardo, Somariva Prophiro Josiane, Fortunato Jucélia J
Neurobiology Laboratory of Inflammatory and Metabolic Processes, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil,
Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil.
Neuropsychiatr Dis Treat. 2019 Mar 11;15:669-673. doi: 10.2147/NDT.S193896. eCollection 2019.
The neurodevelopment period is susceptible to alterations by genetic and environmental factors, such as the exposure to organophosphates (OP). The OP is neurotoxic and has been associated with neurological diseases pathophysiology. The OP temephos is widely used against in Brazil's public health programs.
To evaluate behavioral effects of prenatal exposition to temephos in rats.
First, we divided pregnant females into groups: those who received temephos diluted in distilled water by gavage between gestational days 6-13 and those who received only distilled water in the same period and volume. Then, we divided pups according to sex and exposure, and we made the behavioral tests on postnatal day 30.
Prenatal exposure to temephos caused hyperactivity, stereotyped behavior, and social impairment in animals.
These results are similar to the altered behavior presented in some neurobiological diseases models, like Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders, and this study may bring a red alert to the large use of temephos in Brazil, due to the damage caused by its exposure.
神经发育时期易受遗传和环境因素的影响而发生改变，例如接触有机磷（OP）。有机磷具有神经毒性，并与神经疾病的病理生理学相关。在巴西的公共卫生项目中，广泛使用有机磷杀虫剂双硫磷。
评估大鼠产前接触双硫磷的行为影响。
首先，我们将怀孕的雌性大鼠分为几组：在妊娠第6至13天通过灌胃给予双硫磷稀释于蒸馏水中的大鼠，以及在同一时期和相同体积下仅接受蒸馏水的大鼠。然后，我们根据性别和接触情况对幼崽进行分组，并在出生后第30天进行行为测试。
产前接触双硫磷会导致动物多动、刻板行为和社交障碍。
这些结果与一些神经生物学疾病模型（如注意力缺陷多动障碍和自闭症谱系障碍）中表现出的行为改变相似，并且由于双硫磷接触造成的损害，本研究可能会给巴西大量使用双硫磷带来警示。
