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Chemical Biology of Protein N-Terminal Methyltransferases.
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Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT).
J Med Chem. 2018 Feb 22;61(4):1541-1551. doi: 10.1021/acs.jmedchem.7b01422. Epub 2018 Jan 31.
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Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state.
Org Biomol Chem. 2017 Aug 9;15(31):6656-6667. doi: 10.1039/c7ob01357d.
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α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere.
Nat Commun. 2017 Mar 7;8:14678. doi: 10.1038/ncomms14678.
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Facile synthesis of SAM-peptide conjugates through alkyl linkers targeting protein -terminal methyltransferase 1.
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Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev. 2015 Nov 15;29(22):2343-8. doi: 10.1101/gad.270611.115. Epub 2015 Nov 5.
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Molecular basis for histone N-terminal methylation by NRMT1.
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DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression.
Nat Commun. 2015 Jul 22;6:7821. doi: 10.1038/ncomms8821.
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Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesis.
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Identification and Functional Characterizations of N-Terminal α-N-Methylation and Phosphorylation of Serine 461 in Human Poly(ADP-ribose) Polymerase 3.
J Proteome Res. 2015 Jun 5;14(6):2575-82. doi: 10.1021/acs.jproteome.5b00126. Epub 2015 Apr 27.
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