Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Sovetskaya St., 14, 150000 Yaroslavl, Russia.
Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznań University of Medical Sciences, Szamarzewskiego St. 84, 60-569 Poznań, Poland.
Biomolecules. 2021 May 4;11(5):689. doi: 10.3390/biom11050689.
The objective of this study was to evaluate serum, hair, and urinary trace element and mineral content in normal-weight and obese women in relation to metabolic risk factors. A total of 80 women aged 30-70 y.o. were enrolled in the obese group (n = 40) and normal-weight group (n = 40). Serum, hair, and urinary trace element and mineral levels were assessed using inductively coupled plasma spectrometry. Body fat percentage was evaluated using bioimpedance. Obese subjects were characterized by significantly higher body fat percentage, blood pressure, serum triglyceride concentration, and insulin resistance. Serum Ca, Fe, Mg, Se, V, Zn levels, hair Fe, Mg, V content, and urinary Se and V concentrations were found to be lower in obese subjects as compared to lean controls. In turn, serum Cu and urinary Fe levels in obese women were characterized by a significant increase. In multiple regression models serum Cu, Se, and Zn levels were significantly associated with BMI even after adjustment for blood biochemistry, body composition, and blood pressure. Serum trace element and mineral levels also significantly contributed to group discrimination. These findings allow to propose that obesity-associated disturbances in trace element and mineral status may at least partially contribute to metabolic risk in obese subjects.
本研究旨在评估正常体重和肥胖女性的血清、头发和尿液微量元素和矿物质含量与代谢危险因素的关系。共纳入 80 名 30-70 岁的女性，分为肥胖组（n=40）和正常体重组（n=40）。采用电感耦合等离子体质谱法评估血清、头发和尿液微量元素和矿物质水平。使用生物阻抗评估体脂肪百分比。肥胖组的体脂肪百分比、血压、血清甘油三酯浓度和胰岛素抵抗显著更高。与瘦对照组相比，肥胖组的血清 Ca、Fe、Mg、Se、V、Zn 水平、头发 Fe、Mg、V 含量以及尿 Se 和 V 浓度较低。相反，肥胖女性的血清 Cu 和尿 Fe 水平显著增加。在多元回归模型中，即使在校正了血液生化、身体成分和血压后，血清 Cu、Se 和 Zn 水平仍与 BMI 显著相关。血清微量元素和矿物质水平也对组间的区分有显著贡献。这些发现表明，肥胖相关的微量元素和矿物质状态紊乱至少部分导致了肥胖人群的代谢风险。
