Pruski Michal, Lang Bing
Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China.
Critical Care Laboratory, Critical Care Directorate, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
Front Psychiatry. 2019 Mar 4;10:104. doi: 10.3389/fpsyt.2019.00104. eCollection 2019.
Though much progress has been made in recent years towards understanding the function and physiology of primary cilia, they remain a somewhat elusive organelle. Some studies have explored the role of primary cilia in the developing nervous system, and their dysfunction has been linked with several neurosensory deficits. Yet, very little has been written on their potential role in psychiatric disorders. This article provides an overview of some of the functions of primary cilia in signalling pathways, and demonstrates that they are a worthy candidate in psychiatric research. The links between primary cilia and major mental illness have been demonstrated to exist at several levels, spanning genetics, signalling pathways, and pharmacology as well as cell division and migration. The primary focus of this review is on the sensory role of the primary cilium and the neurodevelopmental hypothesis of psychiatric disease. As such, the primary cilium is demonstrated to be a key link between the cellular environment and cell behaviour, and hence of key importance in the considerations of the nature and nurture debate in psychiatric research.
尽管近年来在理解初级纤毛的功能和生理学方面取得了很大进展，但它们仍然是一种有点难以捉摸的细胞器。一些研究探讨了初级纤毛在发育中的神经系统中的作用，其功能障碍与几种神经感觉缺陷有关。然而，关于它们在精神疾病中的潜在作用的文献却很少。本文概述了初级纤毛在信号通路中的一些功能，并表明它们是精神疾病研究中一个值得关注的对象。初级纤毛与主要精神疾病之间的联系已在多个层面得到证实，包括遗传学、信号通路、药理学以及细胞分裂和迁移。本综述的主要重点是初级纤毛的感觉作用以及精神疾病的神经发育假说。因此，初级纤毛被证明是细胞环境与细胞行为之间的关键联系，因此在精神疾病研究中关于先天与后天争论的考量中至关重要。
