Ksir C, Slifer B
Psychopharmacology (Berl). 1982;76(3):286-90. doi: 10.1007/BF00432563.
The effects of several doses of d-amphetamine, chlordiazepoxide (CDP), chlorpromazine (CPZ), LSD, pentobarbital, and scopolamine were examined in rats trained to respond to the brighter of two keys. On each of the 100 trials during a daily session, the rat pressed the key that was brighter (correct key) and received a food pellet, or pressed the incorrect key and terminated the trial without food, or pressed neither key for 10s, allowing the trial to terminate. Within a session, trials were mixed randomly such that on 50 trials the incorrect key was not lit (easy trials) and on 50 trials the incorrect key was dimly lit (difficult trials). Amphetamine (0.5-2.0 mg/kg) reduced percent correct responses, with a greater effect on difficult than on easy trials. CDP (4.0-16.0 mg/kg) and pentobarbital (2.0-16.0 mg/kg) reduced percent correct responses on the difficult trials at the highest doses tested. Scopolamine (0.12-1.0 mg/kg) reduced both percent correct (more so on the difficult trials) and percent of trials on which a response was made, in a dose-related fashion. CPZ (1.0-4.0 mg/kg) reduced trial responding at 2.0 and 4.0 mg/kg and reduced percent correct on the difficult trials at 4.0 mg/kg. LSD (0.08-0.32 mg/kg) did not significantly alter behavior in this study.
在经过训练对两个按键中较亮的按键做出反应的大鼠身上，研究了几种剂量的右旋苯丙胺、氯氮卓（CDP）、氯丙嗪（CPZ）、麦角酸二乙酰胺（LSD）、戊巴比妥和东莨菪碱的作用。在每日实验的100次试验中，大鼠按下较亮的按键（正确按键）并获得一粒食物丸，或者按下错误按键并在没有食物的情况下终止试验，或者10秒内不按任何按键，使试验终止。在一次实验中，试验随机混合，使得在50次试验中错误按键不亮（容易试验），在50次试验中错误按键微亮（困难试验）。苯丙胺（0.5 - 2.0毫克/千克）降低了正确反应的百分比，对困难试验的影响大于对容易试验的影响。在测试的最高剂量下，氯氮卓（4.0 - 16.0毫克/千克）和戊巴比妥（2.0 - 16.0毫克/千克）降低了困难试验中正确反应的百分比。东莨菪碱（0.12 - 1.0毫克/千克）以剂量相关的方式降低了正确反应的百分比（在困难试验中更明显）以及做出反应的试验百分比。氯丙嗪（1.0 - 4.0毫克/千克）在2.0和4.0毫克/千克时减少了试验反应，并在4.0毫克/千克时降低了困难试验中正确反应的百分比。在本研究中，麦角酸二乙酰胺（0.08 - 0.32毫克/千克）未显著改变行为。
