Sublingual immunotherapy with recombinant Mal d 1 downregulates the allergen-specific Th2 response.

作者信息

Kitzmüller Claudia, Jahn-Schmid Beatrice, Kinaciyan Tamar, Bohle Barbara

机构信息

Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

出版信息

Allergy. 2019 Aug;74(8):1579-1581. doi: 10.1111/all.13779. Epub 2019 Apr 10.

DOI:10.1111/all.13779

PMID:30887520

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6767596/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93fe/6767596/3c03c2d50b28/ALL-74-1579-g001.jpg

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Sublingual immunotherapy with recombinant Mal d 1 downregulates the allergen-specific Th2 response.

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本文引用的文献

[1]

Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy.

J Allergy Clin Immunol. 2017-9-1

[2]

Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans.

Cell. 2016-10-20

[3]

Immune mechanisms of sublingual immunotherapy.

Curr Allergy Asthma Rep. 2014-11

[4]

Allergen-specific CD4+ T cell responses in peripheral blood do not predict the early onset of clinical efficacy during grass pollen sublingual immunotherapy.

Clin Exp Allergy. 2012-12

[5]

Oral exposure to Mal d 1 affects the immune response in patients with birch pollen allergy.

J Allergy Clin Immunol. 2012-8-24

[6]

Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy.

J Allergy Clin Immunol. 2011-10-5

[7]

Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion.

Immunity. 2011-1-6

[8]

Birch pollen immunotherapy leads to differential induction of regulatory T cells and delayed helper T cell immune deviation.

J Immunol. 2010-1-4

[9]

Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation.

J Allergy Clin Immunol. 2007-9

[10]

Systemic immunological changes induced by administration of grass pollen allergens via the oral mucosa during sublingual immunotherapy.

Int Arch Allergy Immunol. 1999-11

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Sublingual immunotherapy with recombinant Mal d 1 downregulates the allergen-specific Th2 response.

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