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2
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本文引用的文献

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Native Mass Spectrometry: What is in the Name?原生质谱：名称有何含义？
J Am Soc Mass Spectrom. 2017 Jan 1;28(1):5-13. doi: 10.1021/jasms.8b05378.
2
Topological Analysis of Transthyretin Disassembly Mechanism: Surface-Induced Dissociation Reveals Hidden Reaction Pathways.转甲状腺素蛋白解组装机制的拓扑分析：表面诱导的解离揭示了隐藏的反应途径。
Anal Chem. 2019 Feb 5;91(3):2345-2351. doi: 10.1021/acs.analchem.8b05066. Epub 2019 Jan 28.
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Fourier Transform-Ion Mobility-Orbitrap Mass Spectrometer: A Next-Generation Instrument for Native Mass Spectrometry.傅里叶变换离子淌度-轨道阱质谱仪：用于天然质谱的下一代仪器。
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A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis.一种新型的机械酶切机制是转甲状腺素蛋白淀粉样变性的基础。
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Investigating protein folding and unfolding in electrospray nanodrops upon rapid mixing using theta-glass emitters.使用θ玻璃发射器在快速混合后研究电喷雾纳米液滴中的蛋白质折叠与去折叠。
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Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition.人甲状腺素运载蛋白中新型 Zn2+结合位点：对淀粉样变性和视黄醇结合蛋白识别的影响。
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新型金属诱导转甲状腺素蛋白氧化降解途径研究进展

New insights into the metal-induced oxidative degradation pathways of transthyretin.

机构信息

Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.

出版信息

Chem Commun (Camb). 2019 Apr 2;55(28):4091-4094. doi: 10.1039/c9cc00682f.

DOI:10.1039/c9cc00682f
PMID:30887985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6452628/
Abstract

The amyloidogenic mechanism of transthyretin is still debated but understanding it fully could lend insight into disease progression and potential therapeutics. Transthyretin was investigated revealing a metal-induced (Cr/Cu) oxidation pathway leading to N-terminal backbone fragmentation and oligomer formation; previously hidden details were revealed only by FT-IM-Orbitrap MS and surface-induced dissociation.

摘要

转甲状腺素蛋白的淀粉样变机制仍存在争议，但充分了解这一机制可能有助于深入了解疾病的进展和潜在的治疗方法。通过研究转甲状腺素蛋白，揭示了一种金属诱导（Cr/Cu）氧化途径，导致 N 端骨架断裂和寡聚体形成；只有通过傅里叶变换离子回旋共振轨道阱质谱和表面诱导解离，才揭示了以前隐藏的细节。