Departments of Anesthesiology and.
Family Medicine, University of Michigan, Ann Arbor, MI, United States.
Pain. 2019 May;160(5):1131-1145. doi: 10.1097/j.pain.0000000000001493.
Current guidelines for addressing opioid cessation in the context of chronic pain management recommend that opioids be discontinued if the risks outweigh the benefits. However, few studies have focused on understanding opioid cessation from the perspective of individuals with chronic pain. This mixed-method study included 49 former opioid users with chronic pain and used quantitative survey data and qualitative focus group data to identify themes pertaining to former opioid user's experience before, during, and after opioid cessation. Participants described several reasons for wanting to stop opioids including lack of efficacy, impact on quality of life, and concerns about addiction. Barriers to cessation included concerns about inadequate pain management and concerns about the impact of stopping opioids on mood. After opioid cessation, the sample was mixed regarding the benefit of cessation. Half of the former opioid users reported their pain to be better or the same after stopping opioids; however, 47% of the sample reported feeling worse pain since stopping their opioids. As the pendulum swings from pain control to drug control, we must ensure that the response to the opioid epidemic does not cause harm to individuals with chronic pain. Novel opioid cessation interventions are needed in combination with methods of addressing individual challenges and barriers to adequate pain relief including access to and provision of nonopioid alternatives for pain management.
目前,针对慢性疼痛管理中阿片类药物戒断的指南建议,如果风险大于收益,应停止使用阿片类药物。然而,很少有研究从慢性疼痛患者的角度来关注阿片类药物戒断的问题。这项混合方法研究包括 49 名曾经使用过阿片类药物的慢性疼痛患者,使用定量调查数据和定性焦点小组数据来确定与前阿片类药物使用者在停止阿片类药物使用之前、期间和之后的经历相关的主题。参与者描述了想要停止使用阿片类药物的几个原因,包括缺乏疗效、对生活质量的影响以及对成瘾的担忧。停药的障碍包括对疼痛管理不足的担忧和对停止使用阿片类药物对情绪影响的担忧。停止使用阿片类药物后,样本对停药的益处存在分歧。一半的前阿片类药物使用者报告说,停药后疼痛减轻或与以前一样;然而,47%的样本报告说,自从停止使用阿片类药物后,疼痛更严重了。随着对疼痛控制到药物控制的转变,我们必须确保对阿片类药物流行的反应不会对慢性疼痛患者造成伤害。需要结合解决个体挑战和充分缓解疼痛的障碍的方法,包括获得和提供非阿片类药物替代药物,来开发新的阿片类药物戒断干预措施。