Sherman Benjamin J, Chahla Jorge, Glowney Jason, Frank Rachel M
Orthopedics. 2019 Mar 1;42(2):66-73. doi: 10.3928/01477447-20190225-02.
Individuals with osteoarthritis have a diminished quality of life, and the condition is a major cause of disability. Newer biologic treatments have been developed that are believed to modify disease progression. These predominantly include hyaluronic acid, platelet-rich plasma, bone marrow aspirate concentrate, and adipose-derived mesenchymal stem cells. There is conflicting evidence regarding the use of orthobiologics for osteoarthritis and for focal chondral defects, although most studies indicate that injections of biologics are safe and without significant adverse effects. [Orthopedics. 2019; 42(2):66-73.].
骨关节炎患者的生活质量下降，该病症是导致残疾的主要原因。现已研发出更新的生物治疗方法，据信这些方法可改变疾病进展。这些方法主要包括透明质酸、富血小板血浆、骨髓抽吸浓缩物和脂肪来源的间充质干细胞。关于使用矫形生物制剂治疗骨关节炎和局灶性软骨缺损存在相互矛盾的证据，不过大多数研究表明，注射生物制剂是安全的，且无明显不良反应。[《骨科》。2019年；42(2):66 - 73。]
